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Anti-Casein Kinase 1 delta antibody (ab10877)

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Overview

Product name

Anti-Casein Kinase 1 delta antibody
See all Casein Kinase 1 delta products (5) ...

Description

Goat polyclonal to Casein Kinase 1 delta

Specificity

ab10877 is specific for human casein kinase 1 delta.

Tested applications

ELISA, IHC-Pmore details

Cross reactivity

Reacts with

Mouse, Human

Immunogen

Synthetic peptide, corresponding to amino acids 310 - 327 of Human Casein Kinase 1 delta.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.09% Sodium Azide

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Stem Cells >> Signaling Pathways >> Wnt >> Cytoplasmic
Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Tangles & Tau
Neuroscience >> Neurotransmission >> Intracellular Signaling >> Kinases
Cell Biology >> Apoptosis >> Intracellular >> p53 Pathway
Cell Biology >> Cell Cycle >> Cell Cycle Inhibitors >> p53

  • Immunohistochemistry (PFA perfusion fixed frozen sections) - Casein Kinase 1 delta antibody (ab10877)Immunohistochemistry (PFA perfusion fixed frozen sections) - Casein Kinase 1 delta antibody (ab10877) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab10877 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

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    ELISA

     ELISA: Use at an assay d...Read more →

    ELISA: Use at an assay dependent dilution.

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    IHC-P

     IHC-P: 1/200Perform heat...Read more →

    IHC-P: 1/200Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

Function

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm.

Tissue specificity

Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes.

Involvement in disease

Defects in CSNK1D are a cause of familial advanced sleep-phase syndrome (FASPS) [MIM:604348]. FASPS is characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.

Sequence similarities

Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Contains 1 protein kinase domain.

Post-translational
modifications

Autophosphorylated on serine and threonine residues.

Cellular localization

Cytoplasm. Nucleus.

Target information above from: UniProt accessionP48730 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Casein kinase I delta isoform antibody
  • Casein kinase I isoform delta antibody
  • CKI delta antibody
  • CKI-delta antibody
  • CKId antibody
  • CSNK 1D antibody
  • CSNK1D antibody
  • HCKID antibody
  • KC1D_HUMAN antibody
  • Protein kinase CK1 delta antibody
see all

Database links

Anti-Casein Kinase 1 delta antibody images:

  Immunohistochemistry (PFA perfusion fixed frozen sections) - Casein Kinase 1 delta antibody (ab10877)

Immunohistochemistry (PFA perfusion fixed frozen sections) - Casein Kinase 1 delta antibody (ab10877)

ab10877 at 1/200 dilution staining Casein Kinase 1 delta in mouse skeletal muscle tissue section by Immunohistochemistry (PFA perfusion fixed frozen sections). Tissue samples from 4 to 6 week old BALB/c mice were immediately removed after killing and immersion fixed in Bouin's solution. Primary antibody was used for 40 minutes at RT. Specific antibody binding was visualised by the peroxidase reaction using DAB as substrate-chromogen.

Image from Lohler J et. al., PLoS ONE. 2009; 4(1): e4174 (Fig 2C).

References for Anti-Casein Kinase 1 delta antibody (ab10877)

This product has been referenced in:

  • Löhler Jet al. Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice. PLoS One 4:e4174 (2009). IHC-P; Mouse.Read more (PubMed: 19137063) »
  • Brockschmidt Cet al. Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo. Gut 57:799-806 (2008).Read more (PubMed: 18203806) »

See all 3 publications for this product

Publishing research using ab10877? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"