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Immunohistochemistry (PFA perfusion fixed frozen sections) - Casein Kinase 1 delta antibody (ab10877)
Immunohistochemistry (PFA perfusion fixed frozen sections) - Casein Kinase 1 delta antibody (ab10877)
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Product Name 

Casein Kinase 1 delta antibody

 

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Product type 

Primary antibodies

Description 

Goat polyclonal to Casein Kinase 1 delta

Immunogen 

Synthetic peptide, corresponding to amino acids 310 - 327 of Human Casein Kinase 1 delta.

Reacts with 
(species key)

Hu, Ms

Specificity 

ab10877 is specific for human casein kinase 1 delta.

Tested applications 
(see key)

ELISA, IHC-P


Abreviews 

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(see key)


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Application notes 
(see key)

Recommended dilutions
ELISA: Use at an assay dependent dilution.
IHC-P: 1/200. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Cytoplasmic

Research areas 

Stem Cells >> Signaling Pathways >> Wnt >> Cytoplasmic
Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Tangles & Tau
Neuroscience >> Neurotransmission >> Intracellular Signaling >> Kinases
Cell Biology >> Apoptosis >> Intracellular >> p53 Pathway
Cell Biology >> Cell Cycle >> Cell Cycle Inhibitors >> p53

Relevance 

The casein kinase 1 family of protein kinases is common to all eukaryotic cells, although tissue distribution and subcellular localisation may vary between isoforms. Casein kinase 1 delta has been implicated in the regulation of p53. Upregulation of casein kinase 1 delta expression has been reported in Alzheimer's disease hippocampus and its association with tau-containing bodies suggests that it may play a role in the abnormal phosphorylation of tau.

 

Alternative names Casein Kinase 1 delta antibody (ab10877)

Database links 

The links below go to external sites and will open in a new browser window

Entrez Gene

    

1453    (Human)
104318    (Mouse)

Omim

    

600864    (Human)

SwissProt

    

Q96KZ6    (Human)
Q99KK4    (Mouse)

Unigene

    

378918    (Human)
216227    (Mouse)

Raised in 

Goat

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Whole antiserum

Storage buffer 

Preservative: 0.09% Sodium Azide

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

Concentration not determined - why is this?

Storage instructions 

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

 

At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Casein Kinase 1 delta antibody is on this datasheet. But please do contact us if you would like any reassurance!


See below for Casein Kinase 1 delta antibody images, references, products related to ab10877 and other tools.

 

Casein Kinase 1 delta antibody images:

Product image  Immunohistochemistry (PFA perfusion fixed frozen sections) - Casein Kinase 1 delta antibody (ab10877)

Immunohistochemistry (PFA perfusion fixed frozen sections) - Casein Kinase 1 delta antibody (ab10877)

ab10877 at 1/200 dilution staining Casein Kinase 1 delta in mouse skeletal muscle tissue section by Immunohistochemistry (PFA perfusion fixed frozen sections). Tissue samples from 4 to 6 week old BALB/c mice were immediately removed after killing and immersion fixed in Bouin's solution. Primary antibody was used for 40 minutes at RT. Specific antibody binding was visualised by the peroxidase reaction using DAB as substrate-chromogen.

Image from Lohler J et. al., PLoS ONE. 2009; 4(1): e4174 (Fig 2C).

 

References for Casein Kinase 1 delta antibody (ab10877)

Specific publication references   This product has been used in: (two most recent references)

Lhler J et al. Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice. PLoS One 4:e4174 (2009). IHC-P; Mouse. PubMed: 19137063

Brockschmidt C et al. Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo. Gut 57:799-806 (2008). PubMed: 18203806
If you publish research using ab10877 please let us know so that we can cite the reference on this datasheet.

 

Search PubMed (MEDLINE) for references to Casein Kinase 1 delta

 

Casein Kinase 1 delta antibody - more information

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Casein Kinase 1 delta antibody - related products:

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Other Casein Kinase 1 delta Antibodies

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