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Casein Kinase 1 delta protein (Active) (ab103955)

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Overview

  • Product nameCasein Kinase 1 delta protein (Active)See all Casein Kinase 1 delta proteins and peptides ...
  • Protein descriptionRecombinant full length Human Casein Kinase 1 delta (amino acids 1-415) with N terminal proprietary tag; MWt 72 kDa (UniProt P48730).
  • Uniprot accessionP48730
  • Molecular weight72kDa inclusive of tags
  • Protein length415 amino acids
  • Expression hostBaculovirus infected sf9 cells

    • Properties

  • Purity> 80 % Densitometry
  • Purification notesPurity was determined to be >80% by densitometry.
  • Biological activityThe Specific activity of ab103955 was determined to be 82 nmol/min/mg.
  • E.C. Number2.7.11.1
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.This product is an active protein and may elicit a biological response in vivo, handle with caution.
  • Storage bufferPreservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab103955 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    Functional Studies FuncS: Use at an assay dependent dilution.
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.
    WB WB: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        Casein kinase I delta isoformCasein kinase I isoform deltaCKI delta
        CKI-deltaCKIdCKIdeltaCSNK 1DCSNK1DHCKIDKC1D_HUMANProtein kinase CK1 delta
      see all
  • FunctionCasein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm.
  • Tissue specificityExpressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes.
  • Involvement in diseaseDefects in CSNK1D are a cause of familial advanced sleep-phase syndrome (FASPS) [MIM:604348]. FASPS is characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.
  • Sequence similaritiesBelongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications    Autophosphorylated on serine and threonine residues.
  • Cellular localizationCytoplasm. Nucleus.

    • Target information above from: UniProt accession P48730 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    Casein Kinase 1 delta protein (Active) images

    • Functional Studies - Casein Kinase 1 delta protein (ab103955)
      Functional Studies - Casein Kinase 1 delta protein (ab103955)
      The Specific activity of ab103955 was determined to be 82 nmol/min/mg.
    • SDS-PAGE - Casein Kinase 1 delta protein (ab103955)
      SDS-PAGE - Casein Kinase 1 delta protein (ab103955)
      SDS-PAGE showing ab103955 at approximately 72kDa.

    References for Casein Kinase 1 delta protein (Active) (ab103955)

    ab103955 has not yet been referenced specifically in any publications.

    Publishing research using ab103955 ? Please let us know so that we can cite the reference in this datasheet

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