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- Secondary antibodies
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Product name
Anti-Caspase 1 antibody
See all Caspase 1 products (17) ...
Description
Rabbit polyclonal to Caspase 1
Tested applications
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse, Horse
Immunogen
Synthetic peptide: QTRVLNKEEMEKVKR, corresponding to amino acids 31-45 of Human Caspase 1.
QTRVLNKEEMEKVKR
Positive control
HeLa cell lysate.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: 0.2% Gelatin, PBS
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Metabolism >> Types of disease >> Cancer
Metabolism >> Pathways and Processes >> Metabolism processes >> Apoptosis
Metabolism >> Pathways and Processes >> Metabolism processes >> Hypoxia
Cancer >> Cancer Metabolism >> Response to hypoxia
Cancer >> Invasion/microenvironment >> Apoptosis >> Caspases
Cell Biology >> Apoptosis >> Intracellular >> Caspases etc >> Caspases
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Western blot - Anti-Caspase 1 antibody (ab14368)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab14368 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 45 kDa.
Target
Function
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
Tissue specificity
Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
Sequence similarities
Belongs to the peptidase C14A family.
Contains 1 CARD domain.
Post-translational
modifications
The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
Cellular localization
Cytoplasm.
Target information above from: UniProt accessionP29466
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- CASP 1 antibody
- CASP-1 antibody
- CASP1 antibody
see all
Database links
- Entrez Gene: 834 Human
- Entrez Gene: 12362 Mouse
- Omim: 147678 Human
- SwissProt: Q9TV13 Horse
- SwissProt: P29466 Human
- SwissProt: P29452 Mouse
- Unigene: 2490 Human
- Unigene: 1051 Mouse
Anti-Caspase 1 antibody images:
Western blot - Anti-Caspase 1 antibody (ab14368)
Anti-Caspase 1 antibody (ab14368) at 0.5 µg/ml + Cell lysates prepared from Hela cells
References for Anti-Caspase 1 antibody (ab14368)
ab14368 has not yet been referenced specifically in any publications.
Publishing research using ab14368? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"