Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab54932 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3 µg/ml.
WB Use a concentration of 1 - 5 µg/ml.

Target

  • FunctionThiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
  • Tissue specificityExpressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
  • Sequence similaritiesBelongs to the peptidase C14A family.
    Contains 1 CARD domain.
  • Post-translational
    modifications
    The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • CASP 1 antibody
    • CASP-1 antibody
    • CASP1 antibody
    • CASP1_HUMAN antibody
    • Caspase 1 antibody
    • Caspase 1 apoptosis related cysteine peptidase antibody
    • Caspase 1 apoptosis related cysteine protease antibody
    • Caspase-1 subunit p10 antibody
    • Caspase1 antibody
    • ICE antibody
    • IL 1 beta converting enzyme antibody
    • IL 1BC antibody
    • IL-1 beta-converting enzyme antibody
    • IL-1BC antibody
    • IL1 beta converting enzyme antibody
    • IL1B convertase antibody
    • IL1BC antibody
    • IL1BCE antibody
    • Interleukin 1 beta convertase antibody
    • Interleukin 1 beta convertase precursor antibody
    • Interleukin 1 beta converting enzyme antibody
    • Interleukin 1B converting enzyme antibody
    • Interleukin-1 beta convertase antibody
    • Interleukin-1 beta-converting enzyme antibody
    • P45 antibody
    see all

Anti-Caspase-1 antibody images

  • Caspase-1 antibody (ab54932) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human hepatocellular carcinoma.

  • Western blot against tagged recombinant protein immunogen using ab54932 Caspase-1 antibody at 1ug/ml. Predicted band size of immunogen is 34 kDa

References for Anti-Caspase-1 antibody (ab54932)

This product has been referenced in:
  • Chen Y  et al. MicroRNAs 221/222 and genistein-mediated regulation of ARHI tumor suppressor gene in prostate cancer. Cancer Prev Res (Phila) 4:76-86 (2011). WB ; Human . Read more (PubMed: 21071579) »

See 1 Publication for this product

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