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Products:Neuroscience >> Neurology process >> Neurodegenerative disease >> Huntington's disease
Overview
Product name
Caspase 1 protein (Active)
See all Caspase 1 products (2) ...
Protein description
Recombinant full length protein (Human)
Expression host
E. coli
Properties
Biological activity
Activity : >5000 units/mg
Form
Lyophilised:
Reconstitute to 1 unit per µl in PBS containing 15% glycerol
Storage instructions
Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Concentration
Concentration information loading...
Additional notes
Active caspase 1 is useful in studying enzyme regulation, determining target substrates, screening caspase inhibitors, or as a positive control in caspase activity assays. The active caspase 1 preferentially cleaves caspase-1 substrates (e.g., YVAD-AFC or YVAD-pNA)
Research areas
Cancer >> Cancer Metabolism >> Response to hypoxia
Cancer >> Invasion/microenvironment >> Apoptosis >> Caspases
Cell Biology >> Apoptosis >> Intracellular >> Caspases etc >> Caspases
Neuroscience >> Neurology process >> Neurodegenerative disease >> Huntington's disease
Applications
Show applications key
Our Abpromise guarantee covers the use of ab39901 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
FuncS: Use at an assay dependent dilution. (We recommend using 1 unit/assay for analyzing caspase activity.)
Protein info
Relevance
Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a2b2 tetramer to form the active enzyme. Caspase 1 is similar to the cell death gene CED3 of C. elegans and regulates multiple proinflammatory cytokines, including Interleukin 1b and interferon-gamma-inducing factor. Caspase 1 plays a role in down stream of Caspase 8 which is involved in Fas-mediated apoptosis.
Cellular localization
Cytoplasmic
References for Caspase 1 protein (Active) (ab39901)
ab39901 has not yet been referenced specifically in any publications.
Publishing research using ab39901? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"