Caspase 10 protein (Active) (ab52080)
Constituents: 15% Glycerol, PBS
Our Abpromise guarantee covers the use of ab52080 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
SDS-PAGE: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- ALPS2Apoptotic protease Mch-4CASP 10
- CASP-10CASP10CASPA_HUMANCaspase 10 apoptosis related cysteine peptidaseCaspase-10 subunit p12FADD like ICE2Fas associated death domain proteinFAS-associated death domain protein interleukin-1B-converting enzyme 2FLICE 2FLICE2ICE like apoptotic protease 4ICE-like apoptotic protease 4Interleukin 1B converting enzyme 2MCH 4
-AMC and Asp-Glu-Val-Asp-
Isoform C is proteolytically inactive.
Defects in CASP10 are a cause of familial non-Hodgkin lymphoma (NHL) [MIM:605027]. NHL is a cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss.
Defects in CASP10 are a cause of gastric cancer (GASC) [MIM:613659]. A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
Contains 2 DED (death effector) domains.
modificationsCleavage by granzyme B and autocatalytic activity generate the two active subunits.
Phosphorylated upon DNA damage, probably by ATM or ATR.
References for Caspase 10 protein (Active) (ab52080)
ab52080 has not yet been referenced specifically in any publications.