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Anti-Caspase 12 antibody [14F7] (ab90895)

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Overview

Product name

Anti-Caspase 12 antibody [14F7]
See all Caspase 12 products (7) ...

Description

Rat monoclonal [14F7] to Caspase 12

Tested applications

WBmore details

Cross reactivity

Reacts with

Mouse

Immunogen

Recombinant fragment, corresponding to amino acids 95 - 318 of Mouse Caspase 12

Positive control

L929 cells

Properties

Form

Liquid

Storage instructions

Store at +4°C.

Storage buffer

Preservative: 0.09% Sodium Azide

Concentration

Concentration information loading...

Purity

Protein A purified

Clonality

Monoclonal

Clone number

14F7

Isotype

IgG2a

Research areas

Metabolism >> Pathways and Processes >> Metabolism processes >> Apoptosis
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Other proteases
Cancer >> Invasion/microenvironment >> Apoptosis >> Caspases
Cell Biology >> Apoptosis >> Intracellular >> Caspases etc >> Caspases
Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Proteases

  • Western blot - Caspase 12 antibody [14F7] (ab90895)Western blot - Caspase 12 antibody [14F7] (ab90895) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab90895 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.

Tissue specificity

Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis.

Sequence similarities

Belongs to the peptidase C14A family.
Contains 1 CARD domain.

Target information above from: UniProt accessionQ6UXS9 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • CASP 12 antibody
  • CASP-12 antibody
  • Casp12 antibody
  • CASPC_HUMAN antibody
  • Inactive caspase-12 antibody
see all

Database links

Anti-Caspase 12 antibody [14F7] images:

  Western blot - Caspase 12 antibody [14F7] (ab90895)

Western blot - Caspase 12 antibody [14F7] (ab90895)

All lanes : Anti-Caspase 12 antibody [14F7] (ab90895) at 2 µg/ml

Lane 1 : Lysate from Mouse L929 cell line
Lane 2 : Lysate from Rat PC12 cell line

Secondary
HRP-conjugated anti-rat IgG

Performed under reducing conditions.

Predicted band size : 39 kDa

References for Anti-Caspase 12 antibody [14F7] (ab90895)

This product has been referenced in:

  • Morishima N  et al. An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J Biol Chem 277:34287-94 (2002). WB; Mouse.Read more (PubMed: 12097332) »

See 1 publication for this product

Publishing research using ab90895? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"