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Overview

  • Product nameCaspase 3 peptideSee all Caspase 3 proteins and peptides ...

    • Properties

  • FormLiquid
  • Storage instructionsStore at +4°C.
  • Storage bufferPBS with 100ug BSA 0.1% sodium azide
  • Concentration information loading...
  • Sequence notesSynthetic peptide mapping to the amino terminal domain of human caspase-3 p20 subunit
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab7990 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    Blocking
  • Application notesBlocking peptide for Rabbit polyclonal to Caspase 3 (ab7980)

    • Protein info

    • Alternative names
        A830040C14RikApopainApopain precursor
        Apopain precursorCASP 3CASP-3CASP3CASP3CASP3_HUMANCasp3aCaspase 3Caspase 3 apoptosis related cysteine proteaseCaspase 3 apoptosis related cysteine proteaseCaspase 3 p12 subunitCaspase 3 p17 subunitCaspase 3, apoptosis-related cysteine peptidaseCaspase 3, apoptosis-related cysteine proteaseCaspase 3, apoptosis-related cysteine protease aCaspase-3 subunit p12Caspase3CC3CPP 32CPP 32CPP-32CPP32CPP32BCPP32BCysteine protease CPP32Cysteine protease CPP32EC 3.4.22.56Human cysteine protease CPP32 isoform alpha mRNA complete cdsHuman cysteine protease CPP32 isoform alpha mRNA complete cdsICE3ICE3LICELICEMGC100890MGC93645mldyOTTHUMP00000165052OTTHUMP00000165053OTTHUMP00000165054OTTHUMP00000165055OTTHUMP00000224230OTTHUMP00000224231PARP cleavage proteasePARP cleavage proteaseProcaspase3Protein YamaSCA 1SCA-1SCA1SREBP cleavage activity 1SREBP cleavage activity 1YamaYama proteinYama proteinzgc:100890
      see all
  • FunctionInvolved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-
    -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
  • Tissue specificityHighly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
  • Sequence similaritiesBelongs to the peptidase C14A family.
  • Post-translational
    modifications    Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.
    S-nitrosylated on its catalytic site cysteine in unstimulated human cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol.
  • Cellular localizationCytoplasm.

    • Target information above from: UniProt accession P42574 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for Caspase 3 peptide (ab7990)

    ab7990 has not yet been referenced specifically in any publications.

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    What is the molecular weight of Ab7990?

    Thank you for your enquiry. The molecular weight of ab7990 is 2362.0. Should you require further information please do not hesitate to contact me.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"