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Caspase 6 Inhibitor Drug Detection Kit (ab102494)

Q&A (1)

Overview

  • Product nameCaspase 6 Inhibitor Drug Detection Kit
  • Tests
    100 x 1 assay
  • Sample type
    Adherent cells, Suspension cells
  • Assay typeQuantitative
  • Assay time
    1h 30m
  • Product overview

    Abcam's Caspase 6 Inhibitor Drug Detection Kit provides an effective means for screening caspase inhibitors using fluorometric methods. The assay utilizes synthetic peptide substrate VEID-AFC (AFC, 7-amino-4-trifluoromethyl coumarin). Active caspase 6 cleaves the synthetic substrate to release free AFC which can then be quantified by fluorometry. Compounds to be screened can directly be added to the reaction and the level of inhibition of caspase 6 activity can be determined by comparison of the fluorescence intensity in samples with and without the testing inhibitors.
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  • Notes

    Caspases have been shown to play a crucial role in apoptosis induced by various deleterious and physiologic stimuli. Inhibition of caspases can delay apoptosis, implicating a potential role in drug screening efforts.

  • Tested applicationsFunctional Studies more details

Properties

  • RelevanceCaspases have been shown to play a crucial role in apoptosis induced by various deleterious and physiologic stimuli. Inhibition of caspases can delay apoptosis, implicating a potential role in drug screening efforts.
    • Alternative names
        CASP6 inhibitor

    Applications

    Our Abpromise guarantee covers the use of ab102494 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    Functional Studies FuncS

    Protocols

    References for Caspase 6 Inhibitor Drug Detection Kit (ab102494)

    ab102494 has not yet been referenced specifically in any publications.

    Publishing research using ab102494 ? Please let us know so that we can cite the reference in this datasheet

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    What kind of samples (i.e. blood) can be tested with this kit? If this is for "research use only," why is it called a "Drug Screening Kit?" Does it have clinical implications?

    Thank you for your inquiry. This kit is generally used with cell lysates, but theoretically it could be used for blood and other samples. This kit is intended for research use only because it is not validated for patient clinical samples. It is int...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"