Caspase 9 protein (Active) (ab52203)
Constituents: 15% Glycerol, PBS
Our Abpromise guarantee covers the use of ab52203 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Useful in studying enzyme regulation, determining target substrates, screening caspase inhibitors, or as a positive control in caspase activity assays. We recommend using 1 unit/assay for analyzing caspase activity.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- APAF-3APAF3Apoptosis related cysteine peptidase
- Apoptotic protease Mch-6Apoptotic protease-activating factor 3CASP-9CASP9CASP9_HUMANCaspase 9 apoptosis related cysteine peptidaseCaspase 9 Dominant NegativeCaspase 9cCaspase-9Caspase-9 subunit p10ICE LAP6ICE like apoptotic protease 6ICE-LAP6ICE-like apoptotic protease 6MCH6RNCASP9
Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
Contains 1 CARD domain.
modificationsCleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.
References for Caspase 9 protein (Active) (ab52203)
This product has been referenced in:
- Basu A et al. Proteolytic activation of protein kinase C-epsilon by caspase-mediated processing and transduction of antiapoptotic signals. J Biol Chem 277:41850-6 (2002). Read more (PubMed: 12198125) »
- Azuma T et al. Gelsolin in complex with phosphatidylinositol 4,5-bisphosphate inhibits caspase-3 and -9 to retard apoptotic progression. J Biol Chem 275:3761-6 (2000). Read more (PubMed: 10660524) »