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Product Name
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Cathepsin G antibody
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See all Cathepsin G antibodies (12)...
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Product type
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Primary antibodies
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Description
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Sheep polyclonal to Cathepsin G
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Immunogen
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Human Cathepsin G purified from human neutrophils.
Greater than 95% pure by SDS-PAGE.
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Reacts with
(species key)
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Hu
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Specificity
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This product gives a single arc when tested by IEP and 2D-IEP against human Cathepsin G.
Identity isconfirmed by double diffusion (Ouchterlony) verses human Cathepsin G and a known anti-humanCathepsin G.
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Tested applications
(see key)
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WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
For western blotting:
Antigen: 2µg Cathepsin G
Antibody: 1:500
Secondary Antibody: 1:1000 Donkey a-Sheep/Goat immunoglobulins-peroxidase
Thefollowing dilutions should be used as guidelines for determining those appropriate for the users system.
Suitability for use in nephelometry, immunohistochemical procedures and enzyme-linked immunosorbent assays has not been assessed but use insuch assays should not necessarily be excluded.
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Cellular localization
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Cytoplasmic
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Research areas
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Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> Other Enzymes
Neuroscience >> Cell Adhesion Proteins >> Membrane Proteins
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Relevance
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Cathepsin G is a serine protease, it consisting of a single polypeptide with a molecular weight of 30 kDa as determined by SDS-PAGE. Its substrates are collagen and proteoglycans. Poor regulation of Cathepsin G levels has been associated with various connective tissue disorders, for example pulmonary emphysema and cystic fibrosis.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Sheep
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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IgG fraction
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Storage buffer
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Glycine buffered saline pH7.4, 0.1% Sodium Azide, 0.1% EACA, 0.01% Benzamidine,1mM EDTA Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Storage instructions
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Store at +4°C.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Cathepsin G antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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References for Cathepsin G antibody (ab8816)
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This product has been used in: (two most recent references)
Prince LR et al. Subversion of a lysosomal pathway regulating neutrophil apoptosis by a major bacterial toxin, pyocyanin. J Immunol 180:3502-11 (2008). WB. PubMed: 18292577
Dick EP et al. Ex vivo-expanded bone marrow CD34+ derived neutrophils have limited bactericidal ability. Stem Cells 26:2552-63 (2008). WB; Human. PubMed: 18669908
If you publish research using ab8816 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to Cathepsin G
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Cathepsin G antibody - more information
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