Overview

  • Product nameAnti-Cdc23 antibody
    See all Cdc23 primary antibodies
  • Description
    Rabbit polyclonal to Cdc23
  • Specificityab106496 is predicted not to cross-react with other APC family members. Multiple isoforms of Cdc23 are known to exist.
  • Tested applicationsWB, ICCmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A 17 amino acid synthetic peptide near the center of Human Cdc23 (UniProt Q9UJX2).

  • Positive control
    • K562 cell lysate; K562 cells

Properties

Applications

Our Abpromise guarantee covers the use of ab106496 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: Isoform 1, 69 ; Isoform 3, 56 kDa.
ICC Use a concentration of 5 µg/ml.

Target

  • FunctionComponent of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
  • PathwayProtein modification; protein ubiquitination.
  • Sequence similaritiesBelongs to the APC8/CDC23 family.
    Contains 9 TPR repeats.
  • Post-translational
    modifications
    Phosphorylated. Phosphorylation on Thr-562 occurs specifically during mitosis.
  • Information by UniProt
  • Database links
  • Alternative names
    • ANAPC8 antibody
    • Anaphase promoting complex subunit 8 antibody
    • Anaphase-promoting complex subunit 8 antibody
    • Apc 8 antibody
    • APC8 antibody
    • Cdc 23 antibody
    • CDC23 antibody
    • CDC23_HUMAN antibody
    • cell division cycle 23 antibody
    • Cell division cycle 23 homolog antibody
    • Cell division cycle protein 23 antibody
    • Cell division cycle protein 23 homolog antibody
    • Cut23 antibody
    • Cyclosome subunit 8 antibody
    see all

Anti-Cdc23 antibody images

  • Lane 1 : Anti-Cdc23 antibody (ab106496) at 1 µg/ml
    Lane 2 : Anti-Cdc23 antibody (ab106496) at 2 µg/ml

    Lane 1 : K562 cell lysate
    Lane 2 : K562 cell lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : Isoform 1, 69 ; Isoform 3, 56 kDa
  • ab106496, at 5 µg/ml, staining Cdc23 in K562 cells by Immunocytochemistry.

References for Anti-Cdc23 antibody (ab106496)

ab106496 has not yet been referenced specifically in any publications.

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"