Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Sequence
      KKKVSRSGLYRSPSMPENLNRPR
    • Amino acids
      205 to 225

Specifications

Our Abpromise guarantee covers the use of ab204854 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    HPLC

    Functional Studies

  • Form
    Lyophilised
  • Additional notes

    ab204854 (Cdc25C peptide) can be utilized as a substrate for the following active protein kinases:

     

    ab139629 (Active human BRSK2 full length protein)
    ab60762 (Active human Chk1 full length protein)
    ab69918 (Active human Chk1 full length protein)
    ab119135 (Active human MARK2 full length protein)
    ab60012 (Active human Mark3 full length protein)
    ab105211 (Active human MARK4 full length protein)
    ab179497 (Active human Serine/threonine-protein kinase NIM1 full length protein)
    ab125626 (Active human ARK5 full length protein)
    ab105209 (Active human NUAK2 full length protein)

     

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

  • Reconstitution
    Dilute peptide in distilled water to a final concentration of 1 mg/ml. For optimal storage, aliquot diluted product into smaller quantities and store at recommended temperature.

General Info

  • Alternative names
    • CDC 25
    • Cdc 25C
    • CDC25
    • CDC25C
    • Cell division cycle 25 homolog C
    • Cell division cycle 25C
    • Cell division cycle 25C protein
    • Dual specificity phosphatase Cdc25C
    • M phase inducer phosphatase 3
    • M-phase inducer phosphatase 3
    • Mitosis inducer CDC25
    • MPIP3
    • MPIP3_HUMAN
    • Phosphotyrosine phosphatase
    • PPP1R60
    • protein phosphatase 1, regulatory subunit 60
    see all
  • Function
    Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDK1 and activate its kinase activity.
  • Sequence similarities
    Belongs to the MPI phosphatase family.
    Contains 1 rhodanese domain.
  • Developmental stage
    Expressed predominantly in G2 phase.
  • Post-translational
    modifications
    Phosphorylated by CHK1 on Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase. Phosphorylated by PLK4.
  • Cellular localization
    Nucleus.
  • Information by UniProt

References for Cdc25C peptide (ab204854)

ab204854 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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