Overview
- Product nameAnti-Cdk9 antibodySee all Cdk9 primary antibodies ...
- DescriptionRabbit polyclonal to Cdk9
- Specificityab10874 does not cross react with other cyclin dependent kinases.
- Tested applicationsELISA, IHC-P, RIA, WB, IHC-Fr, IP more details
- Species reactivityReacts with: Mouse, Rat, Human
- Immunogen
Full length fusion protein corresponding to human Cdk9.
Properties
- FormLiquid
- Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: 0.01% Sodium Azide
Constituents: Whole Serum - PurityWhole antiserum
- Purification notesWhole serum is supplied delipidised.
- Clonality Polyclonal
- IsotypeIgG
- Research Areas
Applications
Our Abpromise guarantee covers the use of ab10874 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Notes |
|---|---|
| ELISA | ELISA: 1/500 - 1/2000. |
| IHC-P | IHC-P: 1/200 - 1/1000. |
| RIA | RIA: Use at an assay dependent dilution. |
| WB | WB: 1/500 - 1/1000. Predicted molecular weight: 44.6 kDa. |
| IHC-Fr | IHC-Fr: Use at an assay dependent dilution. |
| IP | IP: Use at an assay dependent dilution. |
Target
- FunctionMember of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II), SUPT5H and RDBP. The CDK9/cyclin-K complex has also a kinase activity toward CTD of RNAP II and can substitute for P-TEFb in vitro.
- Tissue specificityUbiquitous.
- Sequence similaritiesBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Contains 1 protein kinase domain. - Cellular localizationNucleus.
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Database links
- Entrez Gene: 1025 Human
- Entrez Gene: 1025 Human
- Entrez Gene: 1025 Human
- Entrez Gene: 107951 Mouse
- Entrez Gene: 362110 Rat
- Omim: 603251 Human
- SwissProt: P50750 Human
- SwissProt: P50750 Human
- SwissProt: P50750 Human
- SwissProt: Q99J95 Mouse
- SwissProt: Q641Z4 Rat
- Unigene: 150423 Human
- Unigene: 706809 Human
- Unigene: 27557 Mouse
- Unigene: 98228 Rat
see all
Target information above from: UniProt accession
P50750
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010)
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Alternative names
- C 2k antibodyC-2K antibodyCDC2 related kinase antibody
- CDC2L4 antibodyCdk 9 antibodyCdk9 antibodyCDK9_HUMAN antibodyCell division cycle 2 like protein kinase 4 antibodyCell division cycle 2-like protein kinase 4 antibodyCell division protein kinase 9 antibodyCTK1 antibodyCyclin dependent kinase 9 antibodyCyclin-dependent kinase 9 antibodyPITALRE antibodySerine threonine protein kinase PITALRE antibodySerine/threonine-protein kinase PITALRE antibodyTAK antibodyTat associated kinase complex catalytic subunit antibody
see all
References for Anti-Cdk9 antibody (ab10874)
ab10874 has not yet been referenced specifically in any publications.
