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Overview

  • Product nameCdk9 protein (Tagged)See all Cdk9 proteins and peptides ...
  • Protein descriptionRecombinant full length human Cdk9 with N-terminal proprietary tag expressed in a Baculovirus infected Sf9 cell expression system; amino acids 1-372, 68kDa. Swiss ID = P50750.
  • Expression hostBaculovirus infected sf9 cells

    • Properties

  • Purification notesPurity was determined to be >85% by densitometry.
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 25% Glycerol, 50mM Sodium chloride, 50mM Tris HCl, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab85603 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB WB: Use at an assay dependent dilution.
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.
  • Application notesThis peptide can be used with studies using ab38840 and ab76873.

    • Protein info

    • Alternative names
        C-2KCDC2 related kinaseCDC2L4
        Cdk 9Cdk9CDK9_HUMANCell division cycle 2-like protein kinase 4Cell division protein kinase 9CTK1Cyclin dependent kinase 9Cyclin-dependent kinase 9PITALRESerine/threonine-protein kinase PITALRETAKTat associated kinase complex catalytic subunit
      see all
  • FunctionMember of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II), SUPT5H and RDBP. The CDK9/cyclin-K complex has also a kinase activity toward CTD of RNAP II and can substitute for P-TEFb in vitro.
  • Tissue specificityUbiquitous.
  • Sequence similaritiesBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
    Contains 1 protein kinase domain.
  • Cellular localizationNucleus.

    • Target information above from: UniProt accession P50750 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    Cdk9 protein (Tagged) images

    References for Cdk9 protein (Tagged) (ab85603)

    ab85603 has not yet been referenced specifically in any publications.

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