Overview

  • Product name
    Anti-Cellular Apoptosis Susceptibility antibody
    See all Cellular Apoptosis Susceptibility primary antibodies
  • Description
    Rabbit polyclonal to Cellular Apoptosis Susceptibility
  • Specificity
    Ab27518 recognises Cellular Apoptosis Susceptibility protein.
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide from N terminus of human Cellular Apoptosis Susceptibility.

  • Positive control
    • Human Liver carcinoma, HeLa cells and NIH 3T3 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab27518 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IHC-P
  • Application notes
    IHC-P: 1/100 for 10 min at room temperature. Boil tissue sections in 10mM citrate buffer, pH 6.0 for 10 min and then cool at room temperature for 20 min.
    WB: Use at a concentration of 0.5 - 2 µg/ml for 2 hours at room temperature. Predicted molecular weight: 110 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
    • Tissue specificity
      Highly expressed in proliferating cells.
    • Sequence similarities
      Belongs to the XPO2/CSE1 family.
      Contains 1 importin N-terminal domain.
    • Cellular localization
      Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • CAS antibody
      • Cellular apoptosis susceptibility protein antibody
      • Chromosome segregation 1 (yeast homolog) like antibody
      • Chromosome segregation 1 Like antibody
      • Chromosome segregation 1 like protein antibody
      • Chromosome segregation 1-like protein antibody
      • Chromosome segregation gene CSE1 antibody
      • CSE 1 antibody
      • CSE 1 chromosome segregation 1 like antibody
      • CSE 1 chromosome segregation 1 like protein antibody
      • CSE 1L antibody
      • CSE1 antibody
      • CSE1 chromosome segregation 1 like (yeast) antibody
      • CSE1 chromosome segregation 1 like antibody
      • CSE1 chromosome segregation 1 like protein antibody
      • CSE1L antibody
      • Exp 2 antibody
      • Exp2 antibody
      • Exportin 2 antibody
      • Exportin-2 antibody
      • Exportin2 antibody
      • Importin alpha re exporter antibody
      • Importin-alpha re-exporter antibody
      • MGC117283 antibody
      • MGC130036 antibody
      • MGC130037 antibody
      • XPO 2 antibody
      • XPO2 antibody
      • XPO2_HUMAN antibody
      see all

    Images

    • Ab27518, at a dilution of 1/100, staining Cellular Apoptosis Susceptibility protein in formalin fixed paraffin embedded human liver carcinoma tissue section by Immunohistochemistry.

    References

    This product has been referenced in:
    • Pupure J  et al. Neuroprotective properties of mildronate, a mitochondria-targeted small molecule. Neurosci Lett 470:100-5 (2010). WB, IHC-P ; Mouse . Read more (PubMed: 20036318) »
    • Wang Y  et al. Quantitative proteomics characterization of a mouse embryonic stem cell model of Down syndrome. Mol Cell Proteomics 8:585-95 (2009). Read more (PubMed: 19001410) »

    See all 2 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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