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Chlamydia trachomatis MOMP protein (His tag) (ab67705)

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Overview

  • Product nameChlamydia trachomatis MOMP protein (His tag)See all Chlamydia trachomatis MOMP proteins and peptides ...
  • Protein descriptionRecombinant fragment, corresponding to amino acids 66-165 of Chlamydia trachomatis MOMP with C terminal 6X His tag.
  • Expression hostE. coli

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Purification notesThis protein is >95% pure as determined by 10% PAGE (coomassie staining) and RP-HPLC. It was purified by proprietary chromatographic techniques.
  • Biological activityThis protein is immunoreactive with sera of Chlamydia Trachomatis infected individuals.
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 8M Urea, 100mM Sodium phosphate, 10mM Tris HCl, pH 6.5
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab67705 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.
    ELISA ELISA: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        Major Outer Membrane ProteinMOMPomp1
        omp1FOmp1L1ompAompIL2
      see all
  • RelevanceChlamydia is caused by the bacterium Chlamydia trachomatis. The intracytoplasmic inclusions caused by the bacterium are draped around the infected cell's nucleus. Chlamydia trachomatis is an intracellular organism that has a genome size of approximately 500-1000 kilobases and contains both RNA and DNA. The organism is also extremely temperature sensitive and must be refrigerated at 4°C as soon as a sample is obtained. Colonization of Chlamydia begins with attachment to sialic acid receptors on the eye, throat or genitalia. It persists at body sites that are inaccessible to phagocytes, T cells, and B cells. It also exists as 15 different serotypes. These serotypes cause four major diseases in humans: endemic trachoma (caused by serotypes A and C), sexually transmitted disease and inclusion conjunctivitis (caused by serotypes D and K), and lymphogranuloma venereum (caused by serotypes L1, L2, and L3). Studies reveal that Chlamydia, because of its cell wall, is able to inhibit phagolysosome fusion in phagocytes. The cell wall is proposed to be Gram negative in that it contains an outer lipopolysaccharide membrane, but it lacks peptidoglycan in its cell wall. This lack of peptidoglycan is shown by the inability to detect muramic acid and antibodies directed against it. It may, however, contain a carboxylated sugar other than muramic acid. The proposed structure consists of a major outer membrane protein cross linked with disulfide bonds. It also contains cysteine rich proteins (CRP) that may be the functional equivalent to peptidoglycan. This unique structure allows for intracellular division and extracellular survival (Hatch 1996). Chlamydia usually infects the cervix and fallopian tubes of women and the urethra of men. Chlamydial infections are believed to be one of the most common of all STDs. It is generally thought that in a population of 15 million, there are up to 300,000 cases of chlamydia each year. Thus, there are many undiagnosed cases of chlamydia in the community. It has been estimated that the true prevalence of chlamydia in the sexually active population may be in the order of 5% to 10%. Chlamydia is one of the leading causes of blindness in underdeveloped countries.
  • Cellular localizationOuter membrane; multi pass membrane protein.

    • References for Chlamydia trachomatis MOMP protein (His tag) (ab67705)

    ab67705 has not yet been referenced specifically in any publications.

    Publishing research using ab67705 ? Please let us know so that we can cite the reference in this datasheet

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    Is the amino acid sequence or host strain/sequence designation available for these proteins, as there is know to be some variation between serovar sequences that may cause lack of reactivity in my testing with certain sera/Abs.

    These are from Serovar E. ab67705 corresponding to amino acids 66-165 ab67706 corresponding to amino acids 191-286 ab67707 corresponding to amino acids 252-354

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"