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RabMAbs (3247-1)

Anti-Cip4 antibody [EPR1966(2)] (ab108277)

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Overview

  • Product nameAnti-Cip4 antibody [EPR1966(2)]See all Cip4 primary antibodies ...
  • Description
    Rabbit monoclonal [EPR1966(2)] to Cip4
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A synthetic peptide corresponding to residues in Human Cip4

  • Positive controlJAR; HepG2; TF1 or HeLa cell lysates
  • General notesProduced under U.S. Patent No. 5,675,063

Properties

Applications

Our Abpromise guarantee covers the use of ab108277 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: 1/1000 - 1/10000. Detects a band of approximately 80 kDa (predicted molecular weight: 68 kDa).
  • Application notesIs unsuitable for ,Flow Cyt,ICC/IF,IHC-P or IP.

    • Target

    • FunctionRequired for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
    • Tissue specificityExpressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea.
    • Sequence similaritiesBelongs to the FNBP1 family.
      Contains 1 FCH domain.
      Contains 1 REM (Hr1) repeat.
      Contains 1 SH3 domain.
    • Post-translational
      modifications      Tyrosine phosphorylated. Also phosphorylated by PKA.
    • Cellular localizationCytoplasm > perinuclear region and Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection > phagocytic cup. Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9.

      • Target information above from: UniProt accession Q15642 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      see all
    • Alternative names
        Cdc42 interacting protein 4 antibodyCdc42 interaction protein 4 long isoform antibodyCdc42-interacting protein 4 antibody
        CG11341 antibodyCG15015 PA antibodyCip 4 antibodyCIP4_HUMAN antibodyDCIP4 antibodyhSTP antibodyProtein Felic antibodySalt tolerant protein antibodySalt tolerator antibodySTOT antibodySTP antibodyThyroid hormone receptor interactor 10 antibodyThyroid receptor interacting protein 10 antibodyThyroid receptor-interacting protein 10 antibodyTR-interacting protein 10 antibodyTRIP 10 antibodyTRIP-10 antibodytrip10 antibodyTruncated Cdc42 interaction protein 4 antibody
      see all

    Anti-Cip4 antibody [EPR1966(2)] images

    • Western blot - Cip4 antibody [EPR1966(2)] (ab108277)
      Western blot - Cip4 antibody [EPR1966(2)] (ab108277)
      All lanes : Anti-Cip4 antibody [EPR1966(2)] (ab108277) at 1/1000 dilution

      Lane 1 : JAR lysate
      Lane 2 : HepG2 lysate
      Lane 3 : TF1 lysate
      Lane 4 : HeLa lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 68 kDa

    References for Anti-Cip4 antibody [EPR1966(2)] (ab108277)

    ab108277 has not yet been referenced specifically in any publications.

    Publishing research using ab108277 ? Please let us know so that we can cite the reference in this datasheet

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