Overview

  • Product nameAnti-Cip4 antibody
    See all Cip4 primary antibodies
  • Description
    Mouse monoclonal to Cip4
  • Tested applicationsWBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: YGLLSEAELE VVPIIAKCLE GMKVAANAVD PKNDSHVLIE LHKSGFARPG DVEFEDFSQP MNRAPSDSSL GTPSDGRPEL RGPGRSRTKR WPFGKKNKT, corresponding to amino acids 231-330 of Human Cip4

Properties

Applications

Our Abpromise guarantee covers the use of ab56545 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionRequired for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
    • Tissue specificityExpressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea.
    • Sequence similaritiesBelongs to the FNBP1 family.
      Contains 1 FCH domain.
      Contains 1 REM (Hr1) repeat.
      Contains 1 SH3 domain.
    • Post-translational
      modifications
      Tyrosine phosphorylated. Also phosphorylated by PKA.
    • Cellular localizationCytoplasm > perinuclear region and Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection > phagocytic cup. Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9.
    • Information by UniProt
    • Database links
    • Alternative names
      • Cdc42 interacting protein 4 antibody
      • Cdc42 interaction protein 4 long isoform antibody
      • Cdc42-interacting protein 4 antibody
      • CG11341 antibody
      • CG15015 PA antibody
      • Cip 4 antibody
      • CIP4_HUMAN antibody
      • DCIP4 antibody
      • hSTP antibody
      • Protein Felic antibody
      • Salt tolerant protein antibody
      • Salt tolerator antibody
      • STOT antibody
      • STP antibody
      • Thyroid hormone receptor interactor 10 antibody
      • Thyroid receptor interacting protein 10 antibody
      • Thyroid receptor-interacting protein 10 antibody
      • TR-interacting protein 10 antibody
      • TRIP 10 antibody
      • TRIP-10 antibody
      • trip10 antibody
      • Truncated Cdc42 interaction protein 4 antibody
      see all

    Anti-Cip4 antibody images

    • Western blot against tagged recombinant protein immunogen using ab56545 Cip4 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-Cip4 antibody (ab56545)

    ab56545 has not yet been referenced specifically in any publications.

    Product Wall

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"