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Product name
Anti-Claudin 1 antibody
See all Claudin 1 products (8) ...
Description
Mouse monoclonal to Claudin 1
Tested applications
WB, IHC-Pmore details
Cross reactivity
Reacts with
Human
Immunogen
Recombinant full length protein, corresponding to amino acids 1-212 of Human Claudin 1
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Isotype
IgG2a
Light chain type
kappa
Research areas
Signal Transduction >> Cytoskeleton / ECM >> Cell Adhesion >> Tight Junctions
Applications
Show applications key
Our Abpromise guarantee covers the use of ab56417 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 23 kDa.
IHC-P: Use a concentration of 3 µg/ml.
Target
Function
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity (By similarity). Acts as a co-receptor for HCV entry into hepatic cells.
Tissue specificity
Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.
Involvement in disease
Defects in CLDN1 are the cause of ichthyosis-sclerosing cholangitis neonatal syndrome (NISCH) [MIM:607626]; also called ichthyosis with leukocyte vacuoles alopecia and sclerosing cholangitis (ILVASC). NISCH is a rare autosomal recessive complex ichthyosis syndrome characterized by scalp hypotrichosis, scarring alopecia, vulgar type ichthyosis, and sclerosing cholangitis.
Sequence similarities
Belongs to the claudin family.
Cellular localization
Cell junction > tight junction. Cell membrane.
Target information above from: UniProt accessionO95832
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Claudin-1 antibody
- Claudin1 antibody
- CLD 1 antibody
see all
Database links
- Entrez Gene: 9076 Human
- Omim: 603718 Human
- SwissProt: O95832 Human
- Unigene: 439060 Human
Anti-Claudin 1 antibody images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Claudin 1 antibody (ab56417)
Claudin 1 antibody (ab56417) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human colon.
Western blot - Claudin 1 antibody (ab56417)
Claudin 1 antibody (ab56417) at 1ug/lane + PRC/PRF/5 cell lysate at 25ug/lane.
References for Anti-Claudin 1 antibody (ab56417)
This product has been referenced in:
- Hassan SS et al. The molecular basis for sonographic cervical shortening at term: identification of differentially expressed genes and the epithelial-mesenchymal transition as a function of cervical length. Am J Obstet Gynecol 203:472.e1-472.e14 (2010).Read more (PubMed: 20817141) »
See 1 publication for this product
Publishing research using ab56417? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"