Anti-Claudin 14 antibody (ab19035)
Key features and details
- Goat polyclonal to Claudin 14
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Claudin 14 antibody -
Description
Goat polyclonal to Claudin 14 -
Host species
Goat -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Rat, Cow, Dog, Pig -
Immunogen
Synthetic peptide:
SATHSGYRLNDYV
, corresponding to C terminal amino acids 227-239 of Human Claudin14. -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab19035 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB | (1) |
Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 23 kDa (predicted molecular weight: 26 kDa).
1 hour primary incubation is recommended for this product. |
Notes |
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WB
Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 23 kDa (predicted molecular weight: 26 kDa). 1 hour primary incubation is recommended for this product. |
Target
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Function
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. -
Tissue specificity
Liver, kidney. Also found in ear. -
Involvement in disease
Defects in CLDN14 are the cause of deafness autosomal recessive type 29 (DFNB29) [MIM:605608]. DFNB29 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. -
Sequence similarities
Belongs to the claudin family. -
Cellular localization
Cell junction > tight junction. Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 23562 Human
- Entrez Gene: 304073 Rat
- Omim: 605608 Human
- SwissProt: O95500 Human
- Unigene: 660278 Human
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Alternative names
- AI851731 antibody
- Claudin 14 antibody
- Claudin-14 antibody
see all
Images
Protocols
Datasheets and documents
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Datasheet download
References (3)
ab19035 has been referenced in 3 publications.
- Bolatkan A et al. Downregulation of METTL6 mitigates cell progression, migration, invasion and adhesion in hepatocellular carcinoma by inhibiting cell adhesion molecules. Int J Oncol 60:N/A (2022). PubMed: 34913069
- Jia H et al. Identification of claudin-2, -6, -11 and -14 as prognostic markers in human breast carcinoma. Int J Clin Exp Pathol 12:2195-2204 (2019). PubMed: 31934042
- Sato M et al. Identification of Transcription Factor E3 (TFE3) as a Receptor-independent Activator of G{alpha}16: GENE REGULATION BY NUCLEAR G{alpha} SUBUNIT AND ITS ACTIVATOR. J Biol Chem 286:17766-76 (2011). IHC-P ; Mouse . PubMed: 21454667