Anti-Collagen I + Collagen III antibody (ab36065)

Overview

• Product nameAnti-Collagen I + Collagen III antibodySee all Collagen I + Collagen III primary antibodies ...
• Description
  Rabbit polyclonal to Collagen I + Collagen III
• SpecificityThe antibody shows cross reactivity of: Collagen type III 100%; Collagen type I 91%; Collagen type II <1%; Collagen types IV and V, fibronectin, and albumin <0.5%.
• Tested applicationsICC/IF, ELISA more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Full length native Collagen I + Collagen III proteins (purified) from human placenta.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: 0.1M Sodium chloride, 0.01M Sodium phosphate, 0.01M Sodium borate, pH 7.5, 0.1% mannitol.
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Signal Transduction
  • Cytoskeleton / ECM
  • Extracellular Matrix
  • ECM Proteins
  • Collagen

Applications

Target

• RelevanceCollagen I is a fibrillar collagen found in most connective tissues, and the only component of the collagen found in cartilage. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. Collagen III is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with Collagen I. Mutations in this gene are associated with Ehlers Danlos syndrome type IV, and with aortic and arterial aneurysms. Although alternate transcripts have been detected for this gene, they are the result of mutations; these mutations alter splicing, often leading to the exclusion of multiple exons.
• Cellular localizationSecreted
• Database links
  • Entrez Gene: 1277 Human
  • Entrez Gene: 1278 Human
  • Entrez Gene: 1281 Human
  • Omim: 120150 Human
  • Omim: 120160 Human
  • Omim: 120180 Human
  • SwissProt: P02452 Human
  • SwissProt: P08123 Human

  • SwissProt: P02461 Human
  • Unigene: 172928 Human
  • Unigene: 489142 Human
  • Unigene: 443625 Human

  see all

• Alternative names
  Alpha 1 type I collagen antibodyAlpha 2 type I collagen antibodyCOL1A1 antibody

  COL1A1 antibodyCOL1A2 antibodyCOL3A1 antibodyCollagen fetal antibodyCollagen type I alpha 1 antibodyCollagen type I alpha 2 antibodyCollagen type III alpha 1 antibodyEDS4A antibodyEhlers Danlos syndrome type IV autosomal dominant antibodyOI4 antibodyType I collagen alpha 1 chain antibodyType I procollagen antibody

  see all