Anti-Collagen I + II + III antibody [NLI/22] (ab53925)

Overview

• Product nameAnti-Collagen I + II + III antibody [NLI/22]See all Collagen I + II + III primary antibodies ...
• Description
  Mouse monoclonal [NLI/22] to Collagen I + II + III
• Specificityab53925 does not react with human collagen types IV, V or VI, human plasma proteins or albumin from various species.
• Tested applicationsELISA, ICC/IF more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Full length native protein (purified) (Human)

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: 0.1% mannitol, 0.1M Sodium chloride, 0.01M Sodium phosphate, pH 7.5
• Concentration information loading...
• Purification notesab53925 was purified by Gel Filtration chromatography.
• Clonality Monoclonal
• Clone numberNLI/22
• IsotypeIgM
• Research Areas
  • Signal Transduction
  • Cytoskeleton / ECM
  • Extracellular Matrix
  • ECM Proteins
  • Collagen

Applications

Target

• RelevanceCollagen I is a fibrillar collagen found in most connective tissues, and the only component of the collagen found in cartilage. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. Type II collagen is a fibrillar collagen found in cartilage and the vitreous humor of the eye. Collagen type II is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. Collagen III is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with Collagen I. Mutations in this gene are associated with Ehlers Danlos syndrome type IV, and with aortic and arterial aneurysms. Although alternate transcripts have been detected for this gene, they are the result of mutations; these mutations alter splicing, often leading to the exclusion of multiple exons.
• Database links
  • Entrez Gene: 1280 Human
  • Entrez Gene: 1277 Human
  • Entrez Gene: 1278 Human
  • Entrez Gene: 1281 Human
  • Omim: 120140 Human
  • Omim: 120180 Human
  • Omim: 120150 Human
  • Omim: 120160 Human

  • SwissProt: P02458 Human
  • SwissProt: P02461 Human
  • SwissProt: P02452 Human
  • SwissProt: P08123 Human
  • Unigene: 408182 Human
  • Unigene: 443625 Human
  • Unigene: 172928 Human
  • Unigene: 489142 Human

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• Alternative names
  AOM antibodyCOL11A3 antibodyCOL1A2 antibody

  COL3A1 antibodyCollagen I alpha 1 polypeptide antibodyCollagen I alpha 2 polypeptide antibodyCollagen II alpha 1 polypeptide antibodyCollagen III alpha 1 polypeptide antibodyEDS4A antibodyOI4 antibody

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