You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Anti-Collagen III antibody [3G4] (ab78032)

Submit an Abreview Q&A (1)

Overview

  • Product nameAnti-Collagen III antibody [3G4]See all Collagen III primary antibodies ...
  • Description
    Mouse monoclonal [3G4] to Collagen III
  • SpecificityNo cross-reactivity with human collagen types I, II, IV, V, and VII. We have data to indicate that this antibody may not cross react with Cow. However, this has not been conclusively tested and expression levels may vary in certain cell lines/tissues.
  • Tested applicationsELISA, IP, ICC/IF more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Native human collagen type III

Properties

Applications

Our Abpromise guarantee covers the use of ab78032 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ELISA ELISA: Use at an assay dependent dilution.
IP IP: Use at an assay dependent dilution.
ICC/IF ICC/IF: Use at an assay dependent dilution.

Target

  • FunctionCollagen type III occurs in most soft connective tissues along with type I collagen.
  • Involvement in diseaseDefects in COL3A1 are a cause of Ehlers-Danlos syndrome type 3 (EDS3) [MIM:130020]; also known as benign hypermobility syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS3 is a form of Ehlers-Danlos syndrome characterized by marked joint hyperextensibility without skeletal deformity.
    Defects in COL3A1 are the cause of Ehlers-Danlos syndrome type 4 (EDS4) [MIM:130050]. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS4 is the most severe form of the disease. It is characterized by the joint and dermal manifestations as in other forms of the syndrome, characteristic facial features (acrogeria) in most patients, and by proneness to spontaneous rupture of bowel and large arteries. The vascular complications may affect all anatomical areas.
    Defects in COL3A1 are a cause of susceptibility to aortic aneurysm abdominal (AAA) [MIM:100070]. AAA is a common multifactorial disorder characterized by permanent dilation of the abdominal aorta, usually due to degenerative changes in the aortic wall. Histologically, AAA is characterized by signs of chronic inflammation, destructive remodeling of the extracellular matrix, and depletion of vascular smooth muscle cells.
  • Sequence similaritiesBelongs to the fibrillar collagen family.
    Contains 1 fibrillar collagen NC1 domain.
    Contains 1 VWFC domain.
  • Post-translational
    modifications    Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
    O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.

    • Target information above from: UniProt accession P02461 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        CO3A1_HUMAN antibodyCOL 3A1 antibodyCOL3A1 antibody
        Collagen alpha 1(III) chain antibodyCollagen alpha-1(III) chain antibodyCollagen III alpha 1 chain precursor antibodyCollagen III alpha 1 polypeptide antibodyCollagen type III alpha 1 (Ehlers Danlos syndrome type IV autosomal dominant) antibodyCollagen type III alpha 1 antibodyCollagen type III alpha antibodyEDS4A antibodyEhlers Danlos syndrome type IV, autosomal dominant antibodyFetal collagen antibodyType III collagen antibody
      see all

    References for Anti-Collagen III antibody [3G4] (ab78032)

    ab78032 has not yet been referenced specifically in any publications.

    Publishing research using ab78032 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit an Abreview for ab78032 Submit a Question for ab78032

    Displaying 1 - 1 of 1 results for Abreviews and Q&A

    10
    Votes: Highest First

    Suchen daher monoklonale AK fuer die IHC-P:
    1) gegen Ratte und NICHT gegen Schwein
    2) umgekehrt
    Collagen III oder I
    am liebsten monoklonal (Maus, kann auch Kaninchen sein)

    Vielen Dank für Ihren Anruf.

    Wie versprochen habe ich unsere Kollagen-Antikörper nach den von Ihnen genannten Kriteriengeprüft. Leider habe ich keinen perfekten Treffer gefunden, dafür aber vielleicht ein paar Kandidaten, die...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"