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Anti-Complex I subunit 8 kDa antibody [17C8E4E11 ] (ab110245)

MSCatalog No. MS109

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Overview

Product name

Anti-Complex I subunit 8 kDa antibody [17C8E4E11 ]

Description

Mouse monoclonal [17C8E4E11 ] to Complex I subunit 8 kDa

Tested applications

WBmore details

Cross reactivity

Reacts with

Mouse, Rat, Cow, Human

Immunogen

Bovine Complex I subunit 8 kDa.

Positive control

Isolated mitochondria from Human, Bovine, Rat and Mouse hearts.

Properties

Form

Liquid

Storage instructions

Store at +4°C. Do not freeze.

Storage buffer

Preservative: 0.02% Sodium azide
Constituent: HBS

Concentration

Concentration information loading...

Purification notes

ab110245 was produced in vitro using hybridomas grown in serum-free medium, and then purified by biochemical fractionation.

Clonality

Monoclonal

Clone number

17C8E4E11

Isotype

IgG1

Light chain type

kappa

Research areas

Metabolism >> Types of disease >> Cancer
Metabolism >> Pathways and Processes >> Mitochondrial Metabolism >> Oxidative phosphorylation >> Complex I
Metabolism >> Pathways and Processes >> Redox metabolism >> Oxidative stress
Metabolism >> Pathways and Processes >> Cofactors, Vitamins / minerals >> Vitamins / minerals
Metabolism >> Pathways and Processes >> Mitochondrial Metabolism >> Mitochondrial markers
Cell Biology >> Other Antibodies >> Oxidative Stress
Signal Transduction >> Metabolism >> Vitamins / Minerals
Signal Transduction >> Metabolism >> Mitochondrial

  • Western blot - Anti-Complex I subunit 8 kDa antibody [17C8E4E11 ] (ab110245)Western blot - Anti-Complex I subunit 8 kDa antibody [17C8E4E11 ] (ab110245) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab110245 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Cellular localization

Mitochondrial

Alternative names

  • BC021616 antibody
  • CI23KD antibody
  • TYKY antibody
  • CI 23k antibody
  • MGC101957 antibody
  • MGC37950 antibody
  • MS109 antibody
  • NADH dehydrogenase (ubiquinone) Fe S protein 8, 23kDa (NADH coenzyme Q reductase) antibody
  • NADH ubiquinone oxidoreductase 23 kDa subunit antibody
  • TYKY subunit antibody
see all

Database links

Anti-Complex I subunit 8 kDa antibody [17C8E4E11 ] images:

  Western blot - Anti-Complex I subunit 8 kDa antibody [17C8E4E11 ] (ab110245)

Western blot - Anti-Complex I subunit 8 kDa antibody [17C8E4E11 ] (ab110245)

All lanes : Anti-Complex I subunit 8 kDa antibody [17C8E4E11 ] (ab110245) at 1 µg/ml

Lane 1 : Human heart mitochondria at 10 µg
Lane 2 : Bovine heart mitochondria at 4 µg
Lane 3 : Rat heart mitochondria at 10 µg
Lane 4 : Mouse heart mitochondria at 10 µg

References for Anti-Complex I subunit 8 kDa antibody [17C8E4E11 ] (ab110245)

This product has been referenced in:

  • Keeney PM  et al. Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled. J Neurosci 26:5256-64 (2006).Read more (PubMed: 16687518) »
  • Schilling B  et al. Rapid purification and mass spectrometric characterization of mitochondrial NADH dehydrogenase (Complex I) from rodent brain and a dopaminergic neuronal cell line. Mol Cell Proteomics 4:84-96 (2005).Read more (PubMed: 15591592) »

See all 8 publications for this product

Publishing research using ab110245? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"