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Anti-Complex II Immunocapture antibody [4H12BG12AG2] (ab109865)

MSCatalog No. MS201c

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Overview

Product name

Anti-Complex II Immunocapture antibody [4H12BG12AG2]

Description

Mouse monoclonal [4H12BG12AG2] to Complex II Immunocapture

Specificity

Human, bovine, mouse

Tested applications

IPmore details

Cross reactivity

Reacts with

Mouse, Cow, Human

Immunogen

Bovine Heart Complex II, with traces of Complex III.

Positive control

Bovine heart and Human mitochondria.

Properties

Form

Liquid

Storage instructions

Store at +4°C. Do not freeze.

Storage buffer

Preservative: 0.02% Sodium azide
Constituent: HBS

Concentration

Concentration information loading...

Purification notes

ab109865 was produced in vitro using hybridomas grown in serum-free medium, and then purified by biochemical fractionation.

Clonality

Monoclonal

Clone number

4H12BG12AG2

Isotype

IgG1

Light chain type

kappa

Research areas

Metabolism >> Types of disease >> Cancer
Metabolism >> Pathways and Processes >> Mitochondrial Metabolism >> Mitochondrial markers
Signal Transduction >> Metabolism >> Mitochondrial

  • Immunoprecipitation - Complex II Immunocapture antibody [4H12BG12AG2] (ab109865)Immunoprecipitation - Complex II Immunocapture antibody [4H12BG12AG2] (ab109865) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab109865 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

Complex II is also called succinate ubiquinone oxidoreductase or more commonly succinate dehydrogenase complex. This complex is composed of four nuclear encoded subunits and contains a flavin (FAD), non-heme iron centers and a b-type cytochrome as prosthetic groups. It is both a component of the electron transport chain and an enzyme of the Krebs cycle. Complex II deficiencies are seen in OXPHOS genetic disease and found in a type of cancer called paraganglioma.

Cellular localization

Mitochondrial

Alternative names

  • MS201c antibody

Anti-Complex II Immunocapture antibody [4H12BG12AG2] images:

  Immunoprecipitation - Complex II Immunocapture antibody [4H12BG12AG2] (ab109865)

Immunoprecipitation - Complex II Immunocapture antibody [4H12BG12AG2] (ab109865)

Staining of Complex II Lane 1: 0.1 mg Bovine mitochondrial lysate Lane 2: 0.5 mg Human mitochondrial lysate Immunoprecipitated using ab109865 at 100 µg/mg lysate

References for Anti-Complex II Immunocapture antibody [4H12BG12AG2] (ab109865)

This product has been referenced in:

  • Taanman JW  et al. Characterization of a novel TYMP splice site mutation associated with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). Neuromuscul Disord 19:151-4 (2009).Read more (PubMed: 19056268) »
  • Nadanaciva S  et al. Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays. Toxicol In Vitro 21:902-11 (2007).Read more (PubMed: 17346924) »

See all 4 publications for this product

Publishing research using ab109865? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"