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Products:Signal Transduction >> Cytoskeleton / ECM >> Cell Adhesion >> Gap Junctions
Overview
Product name
Anti-Connexin 40 / GJA5 antibody - Aminoterminal end
See all Connexin 40 / GJA5 products (3) ...
Description
Rabbit polyclonal to Connexin 40 / GJA5 - Aminoterminal end
Tested applications
IHC-P, WB, ELISAmore details
Cross reactivity
Reacts with
Human, Pig
Immunogen
Synthetic peptide selected within aa 100-150 of human Connexin 40 / GJA5.
Positive control
Placenta lysate
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cardiovascular >> Vasculature >> Endothelium
Cardiovascular >> Heart >> Cardiac arrhythmias
Signal Transduction >> Cytoskeleton / ECM >> Cell Adhesion >> Gap Junctions
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Western blot - Connexin 40 / GJA5 antibody (ab38580)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab38580 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: Use at an assay dependent dilution. (See Abreview.)
WB: 1/100 - 1/500.Detects a band of approximately 45 kDa (predicted molecular weight: 40 kDa).
ELISA
ELISA: 1/1000ELISA: 1/1000
Target
Function
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Involvement in disease
Defects in GJA5 are a cause of familial atrial standstill (FAS) [MIM:108770]. Atrial standstill is an extremely rare arrhythmia, characterized by the absence of electrical and mechanical activity in the atria. Electrocardiographically, it is characterized by bradycardia, the absence of P waves, and a junctional narrow complex escape rhythm.
Sequence similarities
Belongs to the connexin family. Alpha-type (group II) subfamily.
Cellular localization
Cell membrane. Cell junction > gap junction.
Target information above from: UniProt accessionP36382
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- connexin 40 antibody
- Connexin-40 antibody
- CX40 antibody
see all
Database links
- Entrez Gene: 2702 Human
- Omim: 121013 Human
- SwissProt: P36382 Human
- Unigene: 447968 Human
Anti-Connexin 40 / GJA5 antibody - Aminoterminal end images:
Western blot - Connexin 40 / GJA5 antibody (ab38580)
Anti-Connexin 40 / GJA5 antibody - Aminoterminal end (ab38580) at 1/100 dilution + Placenta lysate
Predicted band size : 40 kDa
Observed band size : 45 kDa (why is the actual band size different from the predicted?)
References for Anti-Connexin 40 / GJA5 antibody - Aminoterminal end (ab38580)
ab38580 has not yet been referenced specifically in any publications.
Publishing research using ab38580? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"