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Anti-Connexin 40 / GJA5 antibody (ab16585)

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    Overview

    Product name

    Anti-Connexin 40 / GJA5 antibody
    See all Connexin 40 / GJA5 products (3) ...

    Description

    Sheep polyclonal to Connexin 40 / GJA5

    Specificity

    Predicted not to cross react with Connexins 37, 43 or 45.

    Tested applications

    ICC, IFmore details

    Cross reactivity

    Reacts with

    Rat

    Predicted to work with

    Mouse

    Immunogen

    Synthetic peptide conjugated to Diptheria toxoid carrier protein: SLVQGLTPPPDFNQCLK, corresponding to amino acids 254-270 of Rat GJA5.

    SLVQGLTPPP DFNQCLK

    Run BLAST with BLAST the sequence with ExPASyRun BLAST with BLAST the sequence with NCBI

    Positive control

    Cos-7 cells transfected with cDNA encoding GJA5.

    Properties

    Form

    Liquid

    Storage instructions

    Store at +4°C short term (1-2 weeks) (add antibacterial agent). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Storage buffer

    Preservative: None
    Constituents: Whole serum

    Purity

    Whole antiserum

    Clonality

    Polyclonal

    Isotype

    IgG

    Research areas

    Cardiovascular >> Vasculature >> Endothelium
    Cardiovascular >> Heart >> Cardiac arrhythmias
    Signal Transduction >> Cytoskeleton / ECM >> Cell Adhesion >> Gap Junctions

    Applications

    Show applications key

    Our Abpromise guarantee covers the use of ab16585 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • ICC

       ICC: 1/10000 - 1/50000.

      ICC: 1/10000 - 1/50000.

    • IF

       IF: 1/10000 - 1/50000.

      IF: 1/10000 - 1/50000.

    Target

    Function

    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

    Involvement in disease

    Defects in GJA5 are a cause of familial atrial standstill (FAS) [MIM:108770]. Atrial standstill is an extremely rare arrhythmia, characterized by the absence of electrical and mechanical activity in the atria. Electrocardiographically, it is characterized by bradycardia, the absence of P waves, and a junctional narrow complex escape rhythm.

    Sequence similarities

    Belongs to the connexin family. Alpha-type (group II) subfamily.

    Cellular localization

    Cell membrane. Cell junction > gap junction.

    Target information above from: UniProt accessionP36382 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010).

    Information by UniProt

    Alternative names

    • connexin 40 antibody
    • connexin 40 antibody
    • Connexin-40 antibody
    • CX40 antibody
    • CXA5_HUMAN antibody
    • Gap junction alpha 5 protein antibody
    • Gap junction alpha-5 protein antibody
    • gap junction protein alpha 5 40kD (connexin 40) antibody
    • gap junction protein alpha 5 40kD (connexin 40) antibody
    • gap junction protein alpha 5 antibody
    • Gja5 antibody
    • MGC11185 antibody
    see all

    Database links

    References for Anti-Connexin 40 / GJA5 antibody (ab16585)

    ab16585 has not yet been referenced specifically in any publications.

    Publishing research using ab16585? Please let us know so that we can cite the reference in this datasheet

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"