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Anti-Constitutive androstane receptor antibody [N4111] (ab41857)

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Overview

Product name

Anti-Constitutive androstane receptor antibody [N4111]
See all Constitutive androstane receptor products (6) ...

Description

Mouse monoclonal [N4111] to Constitutive androstane receptor

Specificity

This antibody specifically recognizes human CAR but does not recognize human PXR.

Tested applications

ELISA, IP, WBmore details

Cross reactivity

Reacts with

Human

Immunogen

E.coli-expressed recombinant fragment, corresponding to amino acids 76-348 of Human Constitutive androstane receptor.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Mix suspension via gentle inversion before use.

Storage buffer

Preservative: 0.1% Sodium Azide.
Physiological saline.

Concentration

Concentration information loading...

Purification notes

Purified from ascites by ammonium sulfate fractionation.

Clonality

Monoclonal

Clone number

N4111

Myeloma

NS1

Isotype

IgG1

Research areas

Signal Transduction >> Metabolism >> Drug metabolism
Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Orphan Nuclear Receptors
Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Retinoic & Retinoid

Applications

Show applications key

Our Abpromise guarantee covers the use of ab41857 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ELISA

     

  • IP

     

  • WB

     

Application notes

ELISA: Use at a concentration of 0.1 µg/ml.
IP: Use at an assay dependent dilution.
WB: Use at a concentration of 1 µg/ml, (3 µg/ml used under non reducing conditions) Predicted molecular weight: 40 kDa.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

Constitutive androstane receptor (CAR) is a member of orphan receptor. CAR is mainly expressed in liver and lower levels of expression are observed in heart, muscles, kidney and lung. CYP3A and CYP2B are regulated by CAR, which suggest xenobiotics can activate multiple CYP genes through this receptor. Mouse homolog is induced by phenobarbital and CAR-null mouse demonstrate resistance to acetaminophen toxicity. CAR affects metabolism of drugs and other xenobiotics.

Cellular localization

Nucleus (By similarity)

Alternative names

  • CAR antibody
  • CAR BETA antibody
  • CAR1 antibody
  • CARA antibody
  • Constitutive activator of retinoid response antibody
  • Constitutive active response antibody
  • MGC97144 antibody
  • NR1I3 antibody
  • Nuclear receptor subfamily 1 group I member 3 antibody
  • Orphan nuclear receptor MB67 antibody
  • Orphan nuclear receptor NR1I3 antibody
see all

Database links

References for Anti-Constitutive androstane receptor antibody [N4111] (ab41857)

ab41857 has not yet been referenced specifically in any publications.

Publishing research using ab41857? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"