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Product Name
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Constitutive androstane receptor antibody [N4111]
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See all Constitutive androstane receptor antibodies (6)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [N4111] to Constitutive androstane receptor
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Immunogen
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E.coli-expressed recombinant fragment, corresponding to amino acids 76-348 of Human Constitutive androstane receptor.
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Reacts with
(species key)
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Hu
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Specificity
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This antibody specifically recognizes human CAR but does not recognize human PXR.
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Tested applications
(see key)
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ELISA, IP, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ELISA: Use at a concentration of 0.1 µg/ml.
IP: Use at an assay dependent dilution.
WB: Use at a concentration of 1 µg/ml, (3 µg/ml used under non reducing conditions) Predicted molecular weight: 40 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Nucleus (By similarity)
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Research areas
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Signal Transduction >> Metabolism >> Drug metabolism
Chromatin and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Orphan Nuclear Receptors
Chromatin and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Retinoic & Retinoid
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Relevance
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Constitutive androstane receptor (CAR) is a member of orphan receptor. CAR is mainly expressed in liver and lower levels of expression are observed in heart, muscles, kidney and lung. CYP3A and CYP2B are regulated by CAR, which suggest xenobiotics can activate multiple CYP genes through this receptor. Mouse homolog is induced by phenobarbital and CAR-null mouse demonstrate resistance to acetaminophen toxicity. CAR affects metabolism of drugs and other xenobiotics.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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N4111
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Myeloma
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NS1
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Isotype
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IgG1
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Storage buffer
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Preservative: 0.1% Sodium Azide.
Physiological saline. Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Purification notes
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Purified from ascites by ammonium sulfate fractionation.
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Mix suspension via gentle inversion before use.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Constitutive androstane receptor antibody [N4111] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to Constitutive androstane receptor
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Constitutive androstane receptor antibody [N4111] - more information
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