Core Protein p21 antibody - Carboxyterminal end (ab58767)

Product Name 

Core Protein p21 antibody - Carboxyterminal end

Product type 

Primary antibodies

Description 

Rabbit polyclonal to Core Protein p21 - Carboxyterminal end

Immunogen 

A synthetic peptide corresponding to C-terminal residues of Hepatitis C virus Core Protein p21

Reacts with 
(species key)

HCV

Tested applications 
(see key)

ELISA, WB

Abreviews 

Customer reviews (see key)

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Application notes 
(see key)

Recommended dilutions
ELISA: Use at an assay dependent dilution.
WB: Use at a concentration of 1 µg/ml for 2hrs. Predicted molecular weight: 7 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion; Single-pass type I membrane protein. Lipid droplet membrane; Single-pass membrane protein.

Research areas 

Microbiology >> Organism >> Virus >> RNA Virus >> ssRNA positive strand virus >> Hepatitis A/C/E/G
Microbiology >> Organism >> Virus >> RNA Virus >> ssRNA positive strand virus >> HCV

Relevance 

Core protein (Core protein p21 (Capsid protein C) (p21) and Core protein p19) packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Core protein modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Core protein also regulates many host cellular functions such as signaling pathways and apoptosis. It prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation.
Core protein is thought to play a role in virus-mediated cell transformation leading to hepatocellular carcinomas. It interacts with, and activates STAT3 leading to cellular transformation. Core protein may repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm. It also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

Preservative: 0.01% Sodium Azide
Constituents: 50% Glycerol, PBS

Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Sodium Azide MSDS

Form 

Liquid

Concentration 

0.500 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

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