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Products:Microbiology >> Organism >> Virus >> RNA Virus >> ssRNA positive strand virus >> HCV
Overview
Product name
Anti-Core Protein p21 antibody - Carboxyterminal end
Description
Rabbit polyclonal to Core Protein p21 - Carboxyterminal end
Tested applications
WB, ELISAmore details
Cross reactivity
Reacts with
Recombinant Fragment
Predicted to work with
Hepatitis C Virus
Immunogen
A synthetic peptide corresponding to C-terminal residues of Hepatitis C virus Core Protein p21
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.01% Sodium Azide
Constituents: 50% Glycerol, PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Microbiology >> Organism >> Virus >> RNA Virus >> ssRNA positive strand virus >> Hepatitis A/C/E/G
Microbiology >> Organism >> Virus >> RNA Virus >> ssRNA positive strand virus >> HCV
Applications
Show applications key
Our Abpromise guarantee covers the use of ab58767 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 µg/mlPredicted molecular weight: 7 kDa.(for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.)
ELISA: Use at an assay dependent dilution.
Target
Relevance
Core protein (Core protein p21 (Capsid protein C) (p21) and Core protein p19) packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Core protein modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Core protein also regulates many host cellular functions such as signaling pathways and apoptosis. It prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Core protein is thought to play a role in virus-mediated cell transformation leading to hepatocellular carcinomas. It interacts with, and activates STAT3 leading to cellular transformation. Core protein may repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm. It also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation.
Cellular localization
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion; Single-pass type I membrane protein. Lipid droplet membrane; Single-pass membrane protein.
Alternative names
- Capsid protein C antibody
- Core protein antibody
- p21 antibody
Database links
- SwissProt: P27955 Hepatitis C Virus
References for Anti-Core Protein p21 antibody - Carboxyterminal end (ab58767)
ab58767 has not yet been referenced specifically in any publications.
Publishing research using ab58767? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"