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Product Name
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Corticotropin Releasing Factor antibody
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See all Corticotropin Releasing Factor antibodies (9)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to Corticotropin Releasing Factor
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Immunogen
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Synthetic peptide, corresponding to amino acids 1-41 of Rat Corticotropin Releasing Factor.
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Reacts with
(species key)
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Hu, Ms, Rat
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Tested applications
(see key)
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AP, ICC, IHC-P, RIA
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Abreviews
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Application notes
(see key)
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Recommended dilutions
AP: Use at an assay dependent concentration.
ICC: Use at an assay dependent concentration.
IHC-P: Use at an assay dependent dilution.
RIA: Use at an assay dependent concentration.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Secreted
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Research areas
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Neuroscience >> Endocrine system >> hypothalamic pituitary adrenal axis
Signal Transduction >> Growth Factors/Hormones >> Hormones
Neuroscience >> Neurotransmitter >> Neuropeptides >> Hormones
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Relevance
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CRF precursor is a 41-amino acid peptide derived from a 196-amino acid preprohormone. CRF is a neuroendocrine hormone secreted by the paraventricular nucleus (PVN) of the hypothalamus and is a key player in the hypothalamic pituitary adrenal axis. It is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. Neuronal CRF is important in a variety of diverse roles including, memory, depression, stress, kidney function, parturition, metabolism and feeding (to mention a few).
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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IgG fraction
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Storage buffer
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Liquid antiserum
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Form
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Liquid
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Corticotropin Releasing Factor antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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References for Corticotropin Releasing Factor antibody (ab8901)
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This product has been used in: (two most recent references)
Ruggeri RM et al. Immunohistochemical localization and functional characterization of somatostatin receptor subtypes in a corticotropin releasing hormone- secreting adrenal phaeochromocytoma: review of the literature and report of a case. Eur J Histochem 53:1-6 (2009). IHC-P; Human. PubMed: 19351607
Erdmann G et al. Loss of glucocorticoid receptor function in the pituitary results in early postnatal lethality. Endocrinology : (2008). PubMed: 18372328
See all 3 publication references for this product.
If you publish research using ab8901 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to Corticotropin Releasing Factor
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Corticotropin Releasing Factor antibody - more information
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Contact Abcam with a Technical Enquiry about Corticotropin Releasing Factor antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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