Anti-Creatine kinase MT antibody (ab198257)
Key features and details
- Rabbit polyclonal to Creatine kinase MT
- Suitable for: IHC-P, WB
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-Creatine kinase MT antibody
See all Creatine kinase MT primary antibodies -
Description
Rabbit polyclonal to Creatine kinase MT -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, WBmore details -
Species reactivity
Reacts with: Mouse, Human
Predicted to work with: Rat -
Immunogen
Synthetic peptide within Human Creatine kinase MT (internal sequence). The exact sequence is proprietary.
Database link: P12532 -
Positive control
- Mouse crassum intestinum tissue lysate, paraffin-embedded Human tonsil tissue
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab198257 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/50 - 1/200.
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WB |
1/1000 - 1/3000. Predicted molecular weight: 47 kDa.
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Notes |
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IHC-P
1/50 - 1/200. |
WB
1/1000 - 1/3000. Predicted molecular weight: 47 kDa. |
Target
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Relevance
Creatine kinase MT is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Creatine kinase MT occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase, this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. -
Cellular localization
Cell Membrane and Mitochondrial -
Database links
- Entrez Gene: 548596 Human
- Entrez Gene: 12716 Mouse
- Entrez Gene: 29593 Rat
- Omim: 123290 Human
- Omim: 613415 Human
- SwissProt: P12532 Human
- SwissProt: P30275 Mouse
- SwissProt: P25809 Rat
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Alternative names
- Acidic type mitochondrial creatine kinase antibody
- CKMT antibody
- CKMT1 antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab198257 has been referenced in 1 publication.
- Wang Y et al. Low-Dose Delta-9-Tetrahydrocannabinol as Beneficial Treatment for Aged APP/PS1 Mice. Int J Mol Sci 23:N/A (2022). PubMed: 35269905