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Overview

  • Product nameAnti-Cyclin B1 antibody [V143.1]See all Cyclin B1 primary antibodies ...
  • Description
    Mouse monoclonal [V143.1] to Cyclin B1
  • SpecificityExceptionally good at detecting cyclin B1 in western blots, giving a very strong signal with no background.
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Full length protein (Hamster).

  • EpitopeWithin a region spanning the carboxy region.

Properties

Applications

Our Abpromise guarantee covers the use of ab18219 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use at an assay dependent dilution. Predicted molecular weight: 58 kDa.

Target

  • FunctionEssential for the control of the cell cycle at the G2/M (mitosis) transition.
  • Sequence similaritiesBelongs to the cyclin family. Cyclin AB subfamily.
  • Developmental stageAccumulates steadily during G2 and is abruptly destroyed at mitosis.
  • Post-translational
    modifications    Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases.
  • Cellular localizationCytoplasm. Nucleus. Cytoplasm > cytoskeleton > centrosome.

    • Target information above from: UniProt accession P14635 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        CCNB 1 antibodyCCNB antibodyCCNB1 antibody
        CCNB1_HUMAN antibodyG2 mitotic specific cyclin B1 antibodyG2/mitotic-specific cyclin-B1 antibody
      see all

    References for Anti-Cyclin B1 antibody [V143.1] (ab18219)

    This product has been referenced in:
    • Shen W  et al. Female infertility in PDE3A (-/-) mice: Polo-like kinase 1 (Plk1) may be a target of Protein Kinase A (PKA) and involved in meiotic arrest of oocytes from PDE3A (-/- ) mice. Cell Cycle 9:4720-34 (2010). WB ; Mouse . Read more (PubMed: 21099356) »
    • Geley S  et al. Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint. J Cell Biol 153:137-48 (2001). Read more (PubMed: 11285280) »

    See all 3 Publications for this product

    Publishing research using ab18219 ? Please let us know so that we can cite the reference in this datasheet

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