Anti-Cyclin C antibody (ab105046)

Overview

• Product nameAnti-Cyclin C antibodySee all Cyclin C primary antibodies ...
• Description
  Rabbit polyclonal to Cyclin C
• Tested applicationsIHC-P more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide derived from the C terminal region of Human Cyclin C (NP_005181.2)

• Positive controlPancreatic islet cell tumor or skin squamous cell carcinoma.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: 0.1% BSA, Tris buffered saline
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesAffinity purified using an epitope specific to Cyclin C immobilized on solid support.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Epigenetics and Nuclear Signaling
  • Cell cycle
  • Cyclins
  • Other Cyclins

  • Cell Biology
  • Cell Cycle
  • Cyclins
  • Other Cyclins

Applications

Target

• FunctionComponent of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
• Tissue specificityHighest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
• Sequence similaritiesBelongs to the cyclin family. Cyclin C subfamily.
  Contains 1 cyclin N-terminal domain.
• Post-translational
  modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
• Cellular localizationNucleus.

Target information above from: UniProt accession P24863 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 892 Human
  • Omim: 123838 Human
  • SwissProt: P24863 Human
  • Unigene: 430646 Human

• Alternative names
  ccnc antibodyCCNC_HUMAN antibodyCycC antibody

  Cyclin C antibodyCyclin-C antibodyhSRB11 antibodyOTTHUMP00000016897 antibodySRB11 homolog antibody

  see all

Anti-Cyclin C antibody images

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cyclin C antibody (ab105046)
  ab105046 at 1/100 dilution staining Cyclin C in formalin-fixed, paraffin-embedded Human skin squamous cell carcinomatissue.
  Detection: DAB staining.
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cyclin C antibody (ab105046)
  ab105046 at 1/100 dilution staining Cyclin C in formalin-fixed, pParaffin-embedded Human pancreatic islet cell tumor tissue.
  Detection: DAB staining.