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Product Name
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Cyclin D1 antibody
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See all Cyclin D1 antibodies (16)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to Cyclin D1
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Immunogen
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Synthetic peptide (Human) (C terminal).
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Reacts with
(species key)
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Hu, Ms, Rat
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Specificity
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Reacts with cyclin D1 and weakly cross reactive with cyclin D2
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Tested applications
(see key)
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IHC-Fr, IP, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IHC-Fr: Use at an assay dependent dilution.
IP: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 33 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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Jurkat
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Cellular localization
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Nuclear
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Research areas
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Cancer >> Cell cycle >> Cyclins >> Cyclin D family
Chromatin and Nuclear Signaling >> Cell cycle >> Cyclins >> Cyclin D Family
Cell Biology >> Cell Cycle >> Cyclins >> Cyclin D Family
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Relevance
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During each cell cycle cyclins undergo periodic accumulation and destruction. As key regulators of the cell cycle the cyclins control important transitions by acting as regulatory subunits of the Cdks. Early in the G1 phase of the cell cycle, cyclin D1 induction is followed by cyclin E induction. This sequential progression is marked early on in G1 by the activation of Cdk4 and in mid to late G1 by the activation of Cdk2 and the hyperphosphorylation of pRB. The final transition into S phase is thought to be dependent on the increased expression and association of cyclin E and Cdk2.
In a recent study, Cyclin D1 regulates cellular metabolism, fat cell differentiation and cellular migration. Cyclin D1 is also involved in development and cancer.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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IgG fraction
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Storage buffer
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PBS with 0.1% sodium azide Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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0.200 mg/ml
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Storage instructions
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Store at +4°C. Do not freeze.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Cyclin D1 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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References for Cyclin D1 antibody (ab7958)
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This product has been used in: (two most recent references)
Zou Y et al. Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression. J Biol Chem 284:33320-32 (2009). WB; Human. PubMed: 19801544
Dav V et al. Conditional deletion of Pten causes bronchiolar hyperplasia. Am J Respir Cell Mol Biol 38:337-45 (2008). PubMed: 17921358
See all 3 publication references for this product.
If you publish research using ab7958 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to Cyclin D1
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Cyclin D1 antibody - more information
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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