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Products:Cell Biology >> Cell Cycle >> Cyclins >> Cyclin D Family
Overview
Product name
Anti-Cyclin D1 antibody
See all Cyclin D1 products (18) ...
Description
Rabbit polyclonal to Cyclin D1
Specificity
Reacts with cyclin D1 and weakly cross reactive with cyclin D2
Tested applications
IHC-Fr, IP, WBmore details
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
Synthetic peptide (Human) (C terminal).
Positive control
Jurkat
Properties
Form
Liquid
Storage instructions
Store at +4°C. Do not freeze.
Storage buffer
PBS with 0.1% sodium azide
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Cell cycle >> Cyclins >> Cyclin D family
Epigenetics and Nuclear Signaling >> Cell cycle >> Cyclins >> Cyclin D Family
Cell Biology >> Cell Cycle >> Cyclins >> Cyclin D Family
Applications
Show applications key
Our Abpromise guarantee covers the use of ab7958 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-Fr: Use at an assay dependent dilution.
IP: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 33 kDa.
Target
Function
Essential for the control of the cell cycle at the G1/S (start) transition.
Involvement in disease
Note=A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL). Translocation t(11;14)(q13;q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle.
Note=A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas. Translocation t(11;11)(q13;p15) with the parathyroid hormone (PTH) enhancer.
Defects in CCND1 are a cause of multiple myeloma (MM) [MIM:254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving CCND1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus.
Sequence similarities
Belongs to the cyclin family. Cyclin D subfamily.
Post-translational
modifications
Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex.
Ubiquitinated, primarily as 'Lys-48'-linked polyubiquitination. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex containing FBXO4 and CRYAB (By similarity). Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. Ubiquitination leads to its degradation and G1 arrest. Deubiquitinated by USP2; leading to stabilize it.
Cellular localization
Nucleus.
Target information above from: UniProt accessionP24385
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- AI327039 antibody
- B cell ccl/lymphoma 1 antibody
- B cell CLL/lymphoma 1 antibody
see all
Database links
- Entrez Gene: 595 Human
- Entrez Gene: 12443 Mouse
- Entrez Gene: 58919 Rat
- Omim: 168461 Human
- SwissProt: P24385 Human
- SwissProt: P25322 Mouse
- SwissProt: P39948 Rat
- Unigene: 523852 Human
see all
References for Anti-Cyclin D1 antibody (ab7958)
This product has been referenced in:
- Zou Yet al. Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression. J Biol Chem 284:33320-32 (2009). WB; Human.Read more (PubMed: 19801544) »
- Davé Vet al. Conditional deletion of Pten causes bronchiolar hyperplasia. Am J Respir Cell Mol Biol 38:337-45 (2008).Read more (PubMed: 17921358) »
See all 3 publications for this product
Publishing research using ab7958? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"