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Product Name
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Cyclin T1 antibody
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See all Cyclin T1 antibodies (3)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to Cyclin T1
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Immunogen
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Fusion protein (Human).
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Reacts with
(species key)
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Hu, Ms, Rat
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Specificity
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Antiserum will specifically react with an 85 kDa cyclin T1 protein. No reaction was observed against other related cyclins.
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Tested applications
(see key)
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ELISA, IHC-P, IP, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ELISA: 1/500 - 1/2000.
IHC-P: 1/200 - 1/1000.
IP: Use at an assay dependent dilution.
WB: 1/500 - 1/1000. Predicted molecular weight: 81 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Nuclear
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Research areas
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Chromatin and Nuclear Signaling >> Cell cycle >> Cyclins >> Other Cyclins
Cell Biology >> Cell Cycle >> Cyclins >> Other Cyclins
Microbiology >> Interspecies Interaction >> Host Virus Interaction
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Relevance
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Cyclin T1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.
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Cyclin T1 antibody (ab2098) |
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Whole antiserum
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Storage buffer
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serum with 0.01% sodium azide Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Purification notes
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This product was prepared from monospecific antiserum by delipidation and defibrination.
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Form
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Liquid
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Concentration
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Concentration not determined - why is this?
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Cyclin T1 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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References for Cyclin T1 antibody (ab2098)
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This product has been used in: (two most recent references)
Lin C et al. AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia. Mol Cell 37:429-37 (2010). WB, IP. PubMed: 20159561
Guo W et al. Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1). Mol Cancer Ther 8:441-8 (2009). PubMed: 19208825
See all 6 publication references for this product.
If you publish research using ab2098 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to Cyclin T1
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Cyclin T1 antibody - more information
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Customer reviews (feedback) regarding Cyclin T1 antibody |
Customer FAQs regarding Cyclin T1 antibody |
Protocols for Cyclin T1 antibody |
Price and availability of products related to Cyclin T1 antibody |
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Contact Abcam with a Technical Enquiry about Cyclin T1 antibody |
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