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Product name
Cyclopiazonic acid from Penicillium grisefulvum
Description
Ca2+-ATPase inhibitor
Alternative names
- α-Cyclopiazonic acid
Biological description
Cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca2+-ATPase.
Purity
> 99%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Country restrictions and/or license requirements may apply. Please contact customer services for further details.
Properties
Chemical name
(6aR,11aS,11bR)-10-acetyl-2,6,6a,7,11a,11b-hexahydro-11-hydroxy-7,7-dimethyl-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one
Molecular Weight
336.38
Chemical structure
Molecular formula
C20H20N2O3
CAS Number
18172-33-3
Solubility
Soluble in DMSO to 100 mM and in ethanol in 5 mM
Storage instructions
Store at -20°C (desiccating conditions).
Research areas
Biochemicals >> Research Area >> Stroke >> Signaling >> Ca2+ signaling >> Ca2+-ATPase
Biochemicals >> Research Area >> Respiratory disease >> Signaling >> Ca2+ signaling >> Ca2+-ATPase
Biochemicals >> Research Area >> Pain & inflammation >> Signaling >> Ca2+ signaling >> Ca2+-ATPase
Biochemicals >> Research Area >> Obesity >> Signaling >> Ca2+ signaling >> Ca2+-ATPase
Biochemicals >> Research Area >> Hypertension >> Signaling >> Ca2+ signaling >> Ca2+-ATPase
Biochemicals >> Research Area >> Heart disease >> Signaling >> Ca2+ signaling >> Ca2+-ATPase
Biochemicals >> Research Area >> Diabetes >> Signaling >> Ca2+ signaling >> Ca2+-ATPase
Biochemicals >> Research Area >> Cancer >> Signaling >> Ca2+ signaling >> Ca2+-ATPase
Biochemicals >> Research Area >> Alzheimer's Disease >> Signaling >> Ca2+ signaling >> Ca2+-ATPase
Biochemicals >> Research Area >> Stroke >> Calcium
Biochemicals >> Research Area >> Respiratory disease >> Calcium
Biochemicals >> Research Area >> Pain & inflammation >> Calcium
Biochemicals >> Research Area >> Obesity >> Calcium
Biochemicals >> Research Area >> Hypertension >> Calcium
Biochemicals >> Research Area >> Heart disease >> Calcium
Biochemicals >> Research Area >> Diabetes >> Calcium
Biochemicals >> Pharmacology >> Receptors & Transporters >> Transporters >> Ion pumps / transporter >> Ca2+-ATPase >> Inhibitors
Biochemicals >> Pharmacology >> Signaling >> Ca2+ signaling >> Ca2+-ATPase
Biochemicals >> Pharmacology >> Enzymes >> ATPase & GTPase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
References for Cyclopiazonic acid from Penicillium grisefulvum (ab120300)
This product has been referenced in:
- Laursen M et al. Cyclopiazonic acid is complexed to a divalent metal ion when bound to the sarcoplasmic reticulum Ca2+-ATPase. J Biol Chem 284:13513-8 (2009).Read more (PubMed: 19289472) »
- Soler F et al. Cyclopiazonic acid effect on Ca2+-dependent conformational states of the sarcoplasmic reticulum ATPase. Implication for the enzyme turnover. Biochemistry 37:4266-74 (1998).Read more (PubMed: 9521749) »
See all 3 publications for this product
Publishing research using ab120300? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"