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Product name
Cyclosporin A
Description
PP2B inhibitor
Biological description
Immunosuppressant. Complexes with cyclophilin to inhibit the phosphatase activity of calcineurin (PP2B).
Purity
> 99%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
Molecular Weight
1202.63
Chemical structure
Molecular formula
C62H111N11O12
CAS Number
59865-13-3
Solubility
Soluble in DMSO to 100 mM and in ethanol to 50 mM
Storage instructions
Store at -20°C (desiccating conditions).
Research areas
Biochemicals >> Pharmacology >> Enzymes >> Phosphatase >> PP2B >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
References for Cyclosporin A (ab120114)
This product has been referenced in:
- Yu DY et al. Effects of cyclosporin A, FK506 and rapamycin on calcineurin phosphatase activity in mouse brain. IUBMB Life 58:429-33 (2006).Read more (PubMed: 16801218) »
- Ho S et al. The mechanism of action of cyclosporin A and FK506. Clin Immunol Immunopathol 80:S40-5 (1996).Read more (PubMed: 8811062) »
See all 3 publications for this product
Publishing research using ab120114? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"