Overview
Product nameCyclosporin A protein
Protein descriptionCyclosporin A is a cyclic polypeptide consisting of 11 amino acids from Beauveria Nlyea (Molecular weight of 1202.64Da).
Properties
Purification notesPurity is greater than 98.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Mass Spectral Anaylsis {MALDI-TOF exhibits correct Mw}.
FormLyophilised:Reconstitute the lyophilized Cyclosporin A in sterile 18Megaohm-cm H2O at not less than 100µg/ml, which can then be further diluted to other aqueous solutions
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferPreservative: None
Concentration information loading...
Sequence notesChemically, cyclosporin is designated as [R-[R*,R*-(E)]]-cyclic(L-alanyl-D-alanyl -N-methyl-L-leucyl-N-methyl-L-leucyl-N-m ethyl-L-valyl-3-hydroxy-N, 4-dimethyl-L-2-amino-6-octenoyl-L-alpha- amino-butyryl-N-methylglycyl-N-methyl-L- leucyl-L-valyl-N-methyl-L-leucyl). Molecular Formula: C62H111N11O12.
Research Areas
Applications
Our Abpromise guarantee covers the use of
ab73731
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Application
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Notes |
| MS |
MS: Use at an assay dependent dilution. |
Protein info
RelevanceCyclosporin is used to prevent rejection following solid organ and bone marrow transplantation . It has been estimated that cyclosporine is given to more than 90% of children who have received a kidney transplant in the United States. In addition, the ability of cyclosporin to inhibit T-cell activation has been shown to have a role in the treatment of diseases such as nephrotic syndrome, refractory Crohn's disease and ulcerative colitis, biliary cirrhosis, aplastic anemia, rheumatoid arthritis, myasthenia gravis, and dermatomyositis.
Cellular localizationCytoplasmic
References for Cyclosporin A protein (ab73731)
ab73731
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
