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Anti-Cytochrome C Oxidase subunit III antibody [DA5BC4] (ab110259)

MSCatalog No. MS406

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Overview

Product name

Anti-Cytochrome C Oxidase subunit III antibody [DA5BC4]
See all Cytochrome C Oxidase subunit III products (2) ...

Description

Mouse monoclonal [DA5BC4] to Cytochrome C Oxidase subunit III

Tested applications

WBmore details

Cross reactivity

Reacts with

Mouse, Rat, Cow, Human, Saccharomyces cerevisiae

Immunogen

Full length native Cytochrome C Oxidase subunit III (Saccharomyces cerevisiae).

Positive control

Isolated mitochondria from Human , Rat and Mouse hearts.

Properties

Form

Liquid

Storage instructions

Store at +4°C. Do not freeze.

Storage buffer

Preservative: 0.02% Sodium azide
Constituent: HBS

Concentration

Concentration information loading...

Purity

IgG fraction

Purification notes

ab110259 was produced in vitro using hybridomas grown in serum-free medium, and then purified by biochemical fractionation. Near homogeneity ab110259 was judged as near homogeneity by SDS-PAGE.

Clonality

Monoclonal

Clone number

DA5BC4

Isotype

IgG2a

Light chain type

kappa

Research areas

Metabolism >> Types of disease >> Cancer
Metabolism >> Pathways and Processes >> Mitochondrial Metabolism >> Cytochromes
Metabolism >> Pathways and Processes >> Mitochondrial Metabolism >> Oxidative phosphorylation >> Complex IV
Metabolism >> Pathways and Processes >> Redox metabolism >> Oxidative stress
Metabolism >> Pathways and Processes >> Metabolic signaling pathways >> Energy transfer pathways >> Integration of energy
Metabolism >> Pathways and Processes >> Metabolic signaling pathways >> Lipid and lipoprotein metabolism >> Lipases
Metabolism >> Pathways and Processes >> Mitochondrial Metabolism >> Mitochondrial markers
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Integration of energy metabolism
Cell Biology >> Other Antibodies >> Oxidative Stress
Signal Transduction >> Metabolism >> Mitochondrial
Signal Transduction >> Protein Trafficking >> Organelle Proteins
Cardiovascular >> Lipids / Lipoproteins >> Lipid Metabolism >> Cytochromes

  • Western blot - Cytochrome C Oxidase subunit III antibody [DA5BC4] (ab110259)Western blot - Cytochrome C Oxidase subunit III antibody [DA5BC4] (ab110259) image (enlarge)

Applications

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Our Abpromise guarantee covers the use of ab110259 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

Cytochrome C Oxidase subunits I, II and III form the functional core of the enzyme complex. Defects in Cytochrome C Oxidase subunits III are a cause of Leber hereditary optic neuropathy (LHON) and cytochrome c oxidase deficiency (COX deficiency). Defects in Cytochrome C Oxidase subunits III are also found in mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) syndrome and recurrent myoglobinuria.

Cellular localization

Mitochondrion inner membrane; Multi-pass membrane protein.

Alternative names

  • Cytochrome c oxidase polypeptide III antibody
  • Cytochrome c oxidase subunit 3 antibody
  • COIII antibody
  • COX3 antibody
  • COXIII antibody
  • MS406 antibody
  • MT CO3 antibody
  • MTCO3 antibody
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Database links

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Anti-Cytochrome C Oxidase subunit III antibody [DA5BC4] images:

  Western blot - Cytochrome C Oxidase subunit III antibody [DA5BC4] (ab110259)

Western blot - Cytochrome C Oxidase subunit III antibody [DA5BC4] (ab110259)

All lanes : Anti-Cytochrome C Oxidase subunit III antibody [DA5BC4] (ab110259) at 4 µg/ml

Lane 1 : Isolated mitochondria from Human heart at 5 µg
Lane 2 : Isolated mitochondria Rat heart at 10 µg
Lane 3 : Isolated mitochondria from Mouse heart at 10 µg


Predicted band size : 30 kDa

References for Anti-Cytochrome C Oxidase subunit III antibody [DA5BC4] (ab110259)

This product has been referenced in:

  • Feng J  et al. Tyrosine phosphorylation by Src within the cavity of the adenine nucleotide translocase 1 regulates ADP/ATP exchange in mitochondria. Am J Physiol Cell Physiol 298:C740-8 (2010).Read more (PubMed: 20007455) »
  • Minai L  et al. Mitochondrial respiratory chain complex assembly and function during human fetal development. Mol Genet Metab 94:120-6 (2008).Read more (PubMed: 18249146) »

See all 15 publications for this product

Publishing research using ab110259? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"