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Overview

Applications

Our Abpromise guarantee covers the use of ab33484 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ELISA ELISA: 1/2000 - 1/10000.
WB WB: 1/2000 - 1/10000. Detects a band of approximately 12 kDa (predicted molecular weight: 12 kDa).

Target

  • FunctionElectron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
    Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
  • Involvement in diseaseDefects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:612004]; also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.
  • Sequence similaritiesBelongs to the cytochrome c family.
  • Post-translational
    modifications    Binds 1 heme group per subunit.
  • Cellular localizationMitochondrion matrix.

    • Target information above from: UniProt accession P99999 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    see all
  • Alternative names
      CYC antibodyCYC_HUMAN antibodyCYCS antibody
      Cytochrome c antibodyCytochrome c somatic antibodyHCS antibodyTHC4 antibody
    see all

References for Anti-Cytochrome C antibody (ab33484)

This product has been referenced in:
  • Fayad W  et al. Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters. PLoS One 4:e7238 (2009). WB ; Human . Read more (PubMed: 19798419) »

See 1 Publication for this product

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