Overview

  • Product nameAnti-Cytochrome C antibodySee all Cytochrome C primary antibodies ...
  • Description
    Sheep polyclonal to Cytochrome C
  • Tested applicationsWB, IP, ICC/IF more details
  • Species reactivity
    Reacts with: Rat, Rabbit, Dog, Human
  • Immunogen

    Recombinant full length cytochrome C

  • Positive control
    • Rat1 cell lysate

Applications

Our Abpromise guarantee covers the use of ab95018 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB 1/5000. Detects a band of approximately 14.4 kDa.
IP Use at an assay dependent dilution.
ICC/IF Use at an assay dependent dilution.

Target

  • FunctionElectron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
    Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
  • Involvement in diseaseDefects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:612004]; also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.
  • Sequence similaritiesBelongs to the cytochrome c family.
  • Post-translational
    modifications
    Binds 1 heme group per subunit.
  • Cellular localizationMitochondrion matrix.
  • Target information above from: UniProt accession P99999 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
  • Alternative names
    • CYC antibody
    • CYC_HUMAN antibody
    • CYCS antibody
    • Cytochrome c antibody
    • Cytochrome c somatic antibody
    • HCS antibody
    • THC4 antibody
    see all

Anti-Cytochrome C antibody images

  • All lanes : Anti-Cytochrome C antibody (ab95018) at 1/5000 dilution

    Lane 1 : Cytoplasmic fraction from Rat1 cells
    Lane 2 : Membrane fraction from Rat1 cells

References for Anti-Cytochrome C antibody (ab95018)

ab95018 has not yet been referenced specifically in any publications.

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