Cytokeratin 14 protein (Human) (ab73637)
Constituents: 9.5M Urea, 30mM Tris HCl, 2mM EDTA, 10mM methylammonium chloride, pH 8
Our Abpromise guarantee covers the use of ab73637 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|SDS-PAGE||SDS-PAGE: Use at an assay dependent dilution.|
|WB||WB: Use at an assay dependent concentration. Ab73637 can be used as a WB positive control in conjunction with ab7800.|
- CK 14CK-14ck14
- Cytokeratin 14Cytokeratin-14Cytokeratin14Dowling Mearaebs3ebs4Epidermolysis bullosa simplexk14K1C14_HUMANKeratinKeratin 14Keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner)Keratin type I cytoskeletal 14Keratin-14Keratin14KoebnerKrt 14krt14NFJOTTHUMP00000164624type I cytoskeletal 14
Defects in KRT14 are a cause of epidermolysis bullosa simplex Weber-Cockayne type (WC-EBS) [MIM:131800]. WC-EBS is a form of intraepidermal epidermolysis bullosa characterized by blistering limited to palmar and plantar areas of the skin.
Defects in KRT14 are a cause of epidermolysis bullosa simplex Koebner type (K-EBS) [MIM:131900]. K-EBS is a form of intraepidermal epidermolysis bullosa characterized by generalized skin blistering. The phenotype is not fundamentally distinct from the Dowling-Meara type, although it is less severe.
Defects in KRT14 are the cause of epidermolysis bullosa simplex autosomal recessive (AREBS) [MIM:601001]. AREBS is an intraepidermal epidermolysis bullosa characterized by localized blistering on the dorsal, lateral and plantar surfaces of the feet.
Defects in KRT14 are the cause of Naegeli-Franceschetti-Jadassohn syndrome (NFJS) [MIM:161000]; also known as Naegeli syndrome. NFJS is a rare autosomal dominant form of ectodermal dysplasia. The cardinal features are absence of dermatoglyphics (fingerprints), reticular cutaneous hyperpigmentation (starting at about the age of 2 years without a preceding inflammatory stage), palmoplantar keratoderma, hypohidrosis with diminished sweat gland function and discomfort provoked by heat, nail dystrophy, and tooth enamel defects.
Defects in KRT14 are the cause of dermatopathia pigmentosa reticularis (DPR) [MIM:125595]. DPR is a rare ectodermal dysplasia characterized by lifelong persistent reticulate hyperpigmentation, noncicatricial alopecia, and nail dystrophy.
Cytokeratin 14 protein (Human) images
All lanes : Anti-Cytokeratin 14 antibody [LL002] (ab7800) at 2 µg/ml
Lane 1 :
Cytokeratin 14 protein (Human) (ab73637) at 0.1 µg
Lane 2 :
Cytokeratin 14 protein (Human) (ab73637) at 0.01 µg
Goat polyclonal Secondary Antibody to Mouse IgG - H&L (HRP), pre-adsorbed (ab97040) at 1/5000 dilution
developed using the ECL technique
Performed under reducing conditions.
Exposure time : 10 seconds
References for Cytokeratin 14 protein (Human) (ab73637)
ab73637 has not yet been referenced specifically in any publications.