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Overview

  • Product nameAnti-Cytokeratin 4 antibody [6B10], predilutedSee all Cytokeratin 4 primary antibodies ...
  • Description
    Mouse monoclonal [6B10] to Cytokeratin 4, prediluted
  • Tested applicationsIHC-P more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Cytokeratin 4 purified from human esophagus.

  • Positive controlHuman tonsil.

Properties

Applications

Our Abpromise guarantee covers the use of ab75230 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
IHC-P
  • Application notesIHC-P: Ready-to-use. Staining of formalin-fixed tissues requires boiling tissue sections in 1mM EDTA, pH 8.0, for 10-20 min followed by cooling at RT for 20 min.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • Tissue specificityDetected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa (at protein level). Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer.
    • Involvement in diseaseDefects in KRT4 are a cause of white sponge nevus of cannon (WSN) [MIM:193900]. WSN is a rare autosomal dominant disorder which predominantly affects non-cornified stratified squamous epithelia. Clinically, it is characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.
    • Sequence similaritiesBelongs to the intermediate filament family.

      • Target information above from: UniProt accession P19013 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
    • FormLocalisation: Intermediate filament (Cytoskeleton).
      • Alternative names
          CK 4 antibodyCK-4 antibodyCK4 antibody
          CYK4 antibodyCytokeratin 4 antibodyCytokeratin-4 antibodyCytokeratin4 antibodyFLJ31692 antibodyK2C4_HUMAN antibodyK4 antibodyKeratin 4 antibodyKeratin antibodyKeratin type II cytoskeletal 4 antibodyKeratin-4 antibodyKeratin4 antibodyKRT 4 antibodyKRT4 antibodytype II cytoskeletal 4 antibodyType-II keratin Kb4 antibody
        see all

      Anti-Cytokeratin 4 antibody [6B10], prediluted images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cytokeratin 4 antibody [6B10], prediluted (ab75230)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cytokeratin 4 antibody [6B10], prediluted (ab75230)
        Formalin-fixed, paraffin-embedded human tonsil stained with ab75230, using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of mucosal epithelial cells.

      References for Anti-Cytokeratin 4 antibody [6B10], prediluted (ab75230)

      This product has been referenced in:
      • van Muijen GN  et al. Cell type heterogeneity of cytokeratin expression in complex epithelia and carcinomas as demonstrated by monoclonal antibodies specific for cytokeratins nos. 4 and 13. Exp Cell Res 162:97-113 (1986). Read more (PubMed: 2415382) »

      See 1 Publication for this product

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