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Product name
D4476
Description
CK1 inhibitor
Biological description
Selective cell permeable inhibitor of casein kinase 1 (CK1) . (IC50 values are 0.3, 0.5, 9.1 and 5.8 µM for CK1, ALK5, PKd1 and p38aMAPK respectively). Displays selectivity over many other protein kinases.
Purity
> 99%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Molecular Weight
398.41
Chemical structure
Molecular formula
C23H18N4O3
CAS Number
301836-43-1
Solubility
Soluble in DMSO to 100 mM
Storage instructions
Store at +4°C.
Research areas
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> Casein kinase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
References for D4476 (ab120220)
This product has been referenced in:
- Bain J et al. The selectivity of protein kinase inhibitors: a further update. Biochem J 408:297-315 (2007).Read more (PubMed: 17850214) »
- Rena G et al. D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep 5:60-5 (2004).Read more (PubMed: 14710188) »
See all 2 publications for this product
Publishing research using ab120220? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"