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Product Name
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DAP Kinase 1 antibody [DAPK-55]
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See all DAP Kinase 1 antibodies (3)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [DAPK-55] to DAP Kinase 1
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Immunogen
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Recombinant full length protein.
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Reacts with
(species key)
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Hu, Mk
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Tested applications
(see key)
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WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
WB: 1/250. Detects a band of approximately 160 kDa.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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COS-7 whole cell extract.
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Cellular localization
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Cytoplasmic : Colocalizes with the actin filament system.
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Research areas
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Cancer >> Oncoproteins/suppressors >> Tumor suppressors >> Other
Signal Transduction >> Signaling Pathway >> Calcium Signaling >> Calmodulin Pathway
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases
Cell Biology >> Apoptosis >> Intracellular >> Kinases
Cell Biology >> Apoptosis >> Extracellular Signals >> Death Ligands
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Relevance
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DAPK1 (Death-associated protein kinase 1) is a calmodulin dependent serine/threonine serine kinase which functions as a positive mediator of gamma-interferon induced programmed cell death.
DAPK1 expression is frequently lost in human carcinomas and B-cell leukemia, and lower levels of expression correlates with high rates of metastasis. The loss of DAPK expression provides a link between suppression of apoptosis and metastasis. DAPK1 is thought be involved in an early apoptotic checkpoint which eliminates premalignant cells from cancer formation. Studies in bladder cancer patients have also shown that hypermethylation of DAPK1 correlates to high recurrence rates and thus DAPK1 may be used as a prognostic marker. DAPK1 is also reportedly a molecular regulator of neuronal death in epilepsy.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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DAPK-55
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Isotype
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IgG1
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Purity
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Ascites
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Storage buffer
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Preservative: 0.1% Sodium Azide
Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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14.100 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this DAP Kinase 1 antibody [DAPK-55] is on this datasheet. But please do contact us if you would like any reassurance! |
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References for DAP Kinase 1 antibody [DAPK-55] (ab10443)
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This product has been used in:
Puto LA & Reed JC Daxx represses RelB target promoters via DNA methyltransferase recruitment and DNA hypermethylation. Genes Dev 22:998-1010 (2008). PubMed: 18413714
If you publish research using ab10443 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to DAP Kinase 1
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