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Product Name
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DAP Kinase 1 (phospho S308) antibody [DKPS308]
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See all DAP Kinase 1 antibodies (3)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [DKPS308] to DAP Kinase 1 (phospho S308)
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Immunogen
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Synthetic peptide, corresponding to amino acids 303-312 (pSER308) of Human DAP Kinase 1.
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Reacts with
(species key)
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Hu
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Tested applications
(see key)
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Dot, ELISA, IP
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Abreviews
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Application notes
(see key)
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Recommended dilutions
Dot: Use at a concentration of 1 - 2 µg/ml, Determined by immunoblotting using 293T (human embryonal kidney) cells transfected with DAPKinase expression vector.
ELISA: Use at an assay dependent dilution.
IP: Use at an assay dependent dilution.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cytoplasmic : Colocalizes with the actin filament system.
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Research areas
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Cancer >> Oncoproteins/suppressors >> Tumor suppressors >> Other
Signal Transduction >> Signaling Pathway >> Calcium Signaling >> Calmodulin Pathway
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases
Cell Biology >> Apoptosis >> Intracellular >> Kinases
Cell Biology >> Apoptosis >> Extracellular Signals >> Death Ligands
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Relevance
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DAPK1 (Death-associated protein kinase 1) is a calmodulin dependent serine/threonine serine kinase which functions as a positive mediator of gamma-interferon induced programmed cell death.
DAPK1 expression is frequently lost in human carcinomas and B-cell leukemia, and lower levels of expression correlates with high rates of metastasis. The loss of DAPK expression provides a link between suppression of apoptosis and metastasis. DAPK1 is thought be involved in an early apoptotic checkpoint which eliminates premalignant cells from cancer formation. Studies in bladder cancer patients have also shown that hypermethylation of DAPK1 correlates to high recurrence rates and thus DAPK1 may be used as a prognostic marker. DAPK1 is also reportedly a molecular regulator of neuronal death in epilepsy.
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DAP Kinase 1 (phospho S308) antibody [DKPS308] (ab10524) |
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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DKPS308
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Isotype
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IgG1
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Purity
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Immunogen affinity purified
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Storage buffer
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Preservative: 15mM Sodium Azide
Constituents: 0.01mM PBS, pH 7.4 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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2.300 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this DAP Kinase 1 (phospho S308) antibody [DKPS308] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to DAP Kinase 1
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DAP Kinase 1 (phospho S308) antibody [DKPS308] - more information
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Contact Abcam with a Technical Enquiry about DAP Kinase 1 (phospho S308) antibody [DKPS308] |
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