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Anti-DBC1 antibody (ab57608)

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Overview

Product name

Anti-DBC1 antibody
See all DBC1 products (6) ...

Description

Mouse monoclonal to DBC1

Tested applications

WBmore details

Cross reactivity

Reacts with

Human

Immunogen

Recombinant fragment, corresponding to amino acids 5-366 of Human DBC1

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
PBS, pH 7.2

Concentration

Concentration information loading...

Purity

Protein G purified

Clonality

Monoclonal

Isotype

IgG1

Light chain type

kappa

Research areas

Cancer >> Oncoproteins/suppressors >> Tumor suppressors >> p53 pathway
Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Estrogen
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> Nuclear Hormone Receptors >> Estrogen

  • Western blot - DBC1 antibody (ab57608)Western blot - DBC1 antibody (ab57608) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab57608 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application notes

WB: Use at a concentration of 1-5 µg/ml.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

The DBC1 (Deleted in breast cancer 1) amino terminus binds directly to the estrogen receptor alpha (ERalpha) hormone-binding domain in a strict ligand-independent manner. It may function in the modulation of ERalpha expression and hormone-independent breast cancer cell survival. It is ubiquitously expressed in normal tissues. DBC1 promotes p53-mediated apoptosis through specific inhibition of SIRT1.

Cellular localization

Cytoplasmic

Alternative names

  • BA574M5.1 (deleted in bladder cancer chromosome region candidate 1 (IB3089A)) antibody
  • DBC 1 antibody
  • DBC.1 antibody
  • DBCCR1 antibody
  • Deleted in bladder cancer chromosome region candidate 1 antibody
  • Deleted in breast cancer 1 antibody
  • Deleted in breast cancer gene 1 protein antibody
  • FAM5A antibody
  • KIAA1967 antibody
  • OTTHUMP00000022751 antibody
  • p30 DBC antibody
  • p30 DBC protein antibody
  • Protein FAM5A antibody
see all

Database links

Anti-DBC1 antibody images:

  Western blot - DBC1 antibody (ab57608)

Western blot - DBC1 antibody (ab57608)

DBC1 antibody (ab57608) at 1ug/lane + A-549 cell lysate at 25ug/lane.

References for Anti-DBC1 antibody (ab57608)

ab57608 has not yet been referenced specifically in any publications.

Publishing research using ab57608? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"