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Western blot - DBC1 antibody (ab57608)
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Product Name
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DBC1 antibody
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See all DBC1 antibodies (6)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal to DBC1
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Immunogen
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Recombinant full length protein, corresponding to amino acids 5-366 of Human DBC1
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Reacts with
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Hu
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Tested applications
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WB
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Abreviews
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Application notes
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Recommended dilutions
WB: Use at a concentration of 1-5 µg/ml.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Research areas
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Cancer >> Oncoproteins/suppressors >> Tumor suppressors >> p53 pathway
Chromatin and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Estrogen
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> Nuclear Hormone Receptors >> Estrogen
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Relevance
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The DBC1 (Deleted in breast cancer 1) amino terminus binds directly to the estrogen receptor alpha (ERalpha) hormone-binding domain in a strict ligand-independent manner. It may function in the modulation of ERalpha expression and hormone-independent breast cancer cell survival. It is ubiquitously expressed in normal tissues.
DBC1 promotes p53-mediated apoptosis through specific inhibition of SIRT1.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Isotype
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IgG1
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Light chain type
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kappa
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Purity
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Protein G purified
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Storage buffer
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Preservative: None
PBS, pH 7.2
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Form
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Liquid
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Concentration
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0.500 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this DBC1 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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DBC1 antibody images:
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 Western blot - DBC1 antibody (ab57608)
Predicted band size : 103 kDa
DBC1 antibody (ab57608) at 1ug/lane + A-549 cell lysate at 25ug/lane.
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Search PubMed (MEDLINE) for references to DBC1
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DBC1 antibody - more information
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Customer reviews (feedback) regarding DBC1 antibody |
Customer FAQs regarding DBC1 antibody |
Protocols for DBC1 antibody |
Price and availability of products related to DBC1 antibody |
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DBC1 antibody - other tools:
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Contact Abcam with a Technical Enquiry about DBC1 antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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