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Anti-DBC1 antibody (ab70239)

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Overview

Product name

Anti-DBC1 antibody
See all DBC1 products (6) ...

Description

Rabbit polyclonal to DBC1

Tested applications

WB, IPmore details

Cross reactivity

Reacts with

Human

Predicted to work with

Mouse

Immunogen

Synthetic peptide corresponding to a region between residues 1 and 50 of Human DBC1 (SwissProt Q8N163).

Positive control

Nuclear extract from HeLa cells

Properties

Form

Liquid

Storage instructions

Store at +4°C.

Storage buffer

Preservative: 0.09% Sodium Azide
Constituents: 8mM PBS, 60mM Citrate, 150mM Tris, pH 7-8

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

Research areas

Cancer >> Oncoproteins/suppressors >> Tumor suppressors >> p53 pathway
Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Estrogen
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> Nuclear Hormone Receptors >> Estrogen

  • Western blot - DBC1 antibody (ab70239)Western blot - DBC1 antibody (ab70239) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab70239 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide1 Image

    WB

     WB: 1/10000 - 1/20000.De...Read more →

    WB: 1/10000 - 1/20000.Detects a band of approximately 120 kDa (predicted molecular weight: 103 kDa).

  • ShowHide

    IP

     IP: Use at 1-10 µg/mg of...Read more →

    IP: Use at 1-10 µg/mg of lysate.

Target

Relevance

The DBC1 (Deleted in breast cancer 1) amino terminus binds directly to the estrogen receptor alpha (ERalpha) hormone-binding domain in a strict ligand-independent manner. It may function in the modulation of ERalpha expression and hormone-independent breast cancer cell survival. It is ubiquitously expressed in normal tissues. DBC1 promotes p53-mediated apoptosis through specific inhibition of SIRT1.

Cellular localization

Cytoplasmic

Alternative names

  • BA574M5.1 (deleted in bladder cancer chromosome region candidate 1 (IB3089A)) antibody
  • DBC 1 antibody
  • DBC.1 antibody
  • DBCCR1 antibody
  • Deleted in bladder cancer chromosome region candidate 1 antibody
  • Deleted in breast cancer 1 antibody
  • Deleted in breast cancer gene 1 protein antibody
  • FAM5A antibody
  • KIAA1967 antibody
  • OTTHUMP00000022751 antibody
  • p30 DBC antibody
  • p30 DBC protein antibody
  • Protein FAM5A antibody
see all

Database links

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Anti-DBC1 antibody images:

  Western blot - DBC1 antibody (ab70239)

Western blot - DBC1 antibody (ab70239)

All lanes : Anti-DBC1 antibody (ab70239) at 1/10000 dilution

Lane 1 : HeLa cell nuclear extract at 15 µg
Lane 2 : HeLa cell nuclear extract at 45 µg


Predicted band size : 103 kDa
Observed band size : 120 kDa (why is the actual band size different from the predicted?)

References for Anti-DBC1 antibody (ab70239)

ab70239 has not yet been referenced specifically in any publications.

Publishing research using ab70239? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"