Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Products:Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> Nuclear Hormone Receptors >> Estrogen
Overview
Product name
Anti-DBC1 antibody
See all DBC1 products (6) ...
Description
Rabbit polyclonal to DBC1
Tested applications
IHC-Pmore details
Cross reactivity
Reacts with
Mouse, Human
Immunogen
Synthetic peptide corresponding to a region between residues 1 and 50 of Human DBC1 (TrEMBL entry Q6P0Q9)
Positive control
Human: breast carcinoma, colon carcinoma, metastatic lymph node, ovarian carcinoma, pancreatic islet cell tumor, skin basal cell carcinoma, stomach adenocarcinoma, testicular seminoma. Mouse: squamous cell carcinoma.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: 0.1% BSA, Tris buffered saline
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Applications
Show applications key
Our Abpromise guarantee covers the use of ab84384 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 2 Images
IHC-P
Application notes
IHC-P: 1/100 - 1/500. Epitope exposure with citrate buffer will enhance staining.
Note: expected to work on frozen sections.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
The DBC1 (Deleted in breast cancer 1) amino terminus binds directly to the estrogen receptor alpha (ERalpha) hormone-binding domain in a strict ligand-independent manner. It may function in the modulation of ERalpha expression and hormone-independent breast cancer cell survival. It is ubiquitously expressed in normal tissues. DBC1 promotes p53-mediated apoptosis through specific inhibition of SIRT1.
Cellular localization
Cytoplasmic
Alternative names
- BA574M5.1 (deleted in bladder cancer chromosome region candidate 1 (IB3089A)) antibody
- DBC 1 antibody
- DBC.1 antibody
see all
Database links
- Entrez Gene: 1620 Human
- Entrez Gene: 57805 Human
- Entrez Gene: 56710 Mouse
- Omim: 602865 Human
- Omim: 607359 Human
- SwissProt: O60477 Human
- SwissProt: Q8N163 Human
- SwissProt: Q8VDP4 Mouse
see all
Anti-DBC1 antibody images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - DBC1 antibody (ab84384)
Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human breast tumor tissue using 1/250 ab84384, followed by DAB staining.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - DBC1 antibody (ab84384)
Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Mouse squamous cell carcinoma tissue using 1/250 ab84384, followed by DAB staining.
References for Anti-DBC1 antibody (ab84384)
This product has been referenced in:
- Cha EJet al. Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma. Clin Cancer Res 15:4453-9 (2009).Read more (PubMed: 19509139) »
See 1 publication for this product
Publishing research using ab84384? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"